摘要
目的了解哈萨克族食管癌患者血清自身抗体阳性率,探讨自身抗体与哈萨克族食管癌的相关性,为自身抗体应用于食管癌诊断、治疗的潜在可能性提供依据。方法采用1∶2配比的病例对照研究方法,调查92例哈萨克族食管癌患者和184名正常对照,应用间接免疫荧光法（indirect immunofluorescence,IIF）检测哈萨克族食管癌和对照血清中的自身抗体。结果自身抗体阳性率女性高于男性,有随年龄增高而增高的趋势。哈萨克族食管癌患者自身抗体阳性率为50.0%,对照组的自身抗体阳性率为25.0%,差异有统计学意义（P〈0.01）,食管癌患者自身抗体阳性检出几率明显高于对照者,OR=3.78,95%CI=2.11-6.77。结论自身抗体的检测可能有助于食管癌的早期诊断和治疗。
Objective To study the positive rate of autoantibodies in esophageal cancer patients of Kazakhs, to explore the possible relationship between esophageal cancer and the autoantibodies in Kazakhs. Methods A 1：2 matched case - control study was conducted with 92 cases of esophageal cancer patients of Kazakhs and 184 populationbased controls. Using indirected immunofluorescence （IIF）, autoantibodies were detected in patients and controls. Results The positive rate of autoantibodies in female is higher than in male , and with age growing, the positive rate of autoantibodies is higher. The positive rate of autoantibodies in esophageal cancer patients of Kazakhs is 50.0%, in control group is 25.0%, with a difference of X^2M-H= 19.93, df = 1, P 〈 0.01, OR = 3.78, OR95% CI = 2.11, 6677. Conclusion Detection of autoantibodies in esophageal cancer may help in the early diagnosis and treatment.
出处
《中国公共卫生》
CAS
CSCD
北大核心
2008年第5期565-566,共2页
Chinese Journal of Public Health
基金
国家自然科学基金项目(30660161)
2006年教育部科学技术研究重点项目(206167)
石河子大学博士基金(RCZX2004-PB17)
