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柴油机排放颗粒物有机组分的致突变试验 被引量:6

Mutagenicity Test of Various Fractions of Diesel Exhaust Particulates in Vivo and in Vitro
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摘要 采用小鼠骨髓嗜多染红细胞(PCE)及体外培养中国仓鼠卵巢(CHO)细胞,对国产跃进牌中型柴油机排放颗粒物的不同有机组分进行体内及体外微核试验。结果表明:各组分均能引起体内PCE及体外培养CHO细胞微核率的增加,且在一定剂量(浓度)范围内微核率随剂量(浓度)增加而增加,各组分中以有机碱。 The mutagenicities of the various organic fractions of the exhaust particulates from the diesel (trademark:Yuejin) were studied by micronucleus test on bone marrow polychromatid erythrocytes(PCE,in vivo) in mice and Chinese hamster ovarian cells(CHO,in vitro).The results showed that all the five fractions of the diesel exhaust particulates could significantly increase the frequencies of micronucleus of PCE and CHO,in comparison with DMSO control (P<0.05 or P<0.01),and the doseresponse relationships were apparent. The mutagenicities of organic bases,polycyclic aromatic hydrocarbons and polar compounds were higher than those of the other fractions.
出处 《上海实验动物科学》 1997年第4期210-212,共3页 Shanghai Laboratory Animal Science
基金 国家自然科学基金
关键词 环境毒理学 柴油机 排放颗粒物 有机组分 致突变 Diesel exhaust particulate Organic fraction Frequency of micronucleus Mouse Chinese hamster ovarian cell
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