莪棱胶囊对子宫内膜异位症的MMP-7/TIMP-1表达的影响被引量：2

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摘要目的:观察子宫内膜异位症发生与在位、异位内膜上MMP-7、TIMP-1表达水平的关系,及莪棱胶囊对子宫内膜异位症在位、异位内膜上MMP-7、TIMP-1表达的影响,探讨莪棱胶囊的作用机理。方法:将75例子宫内膜异位症患者随机分为3组,即莪棱胶囊组(口服莪棱胶囊)、内美通组(口服内美通)及空白对照组(不服药),每组25例,3个月后行腹腔镜下卵巢巧克力囊肿剔除术,并选取同时期因输卵管阻塞性不孕症行诊刮术的生育年龄妇女17例作为正常对照组。采用免疫组化法检测异位、在位内膜上MMP-7、TIMP-1的表达水平。结果:子宫内膜异位症患者MMP-7表达水平增高,而TIMP-1表达水平下降(P<0.05),服用莪棱胶囊后可以下调MMP-7,而上调TIMP-1的表达水平(P<0.05)。结论:子宫内膜异位症发生与MMP-7/TIMP-1表达失调有关,莪棱胶囊作用机理与调整MMP-7/TIMP-1表达、抑制内膜的侵袭性有关。

作者黄艳辉曹立幸司徒仪

机构地区广州中医药大学第二临床医学院

出处《辽宁中医杂志》 CAS 北大核心 2008年第5期658-660,共3页 Liaoning Journal of Traditional Chinese Medicine

基金广东省自然科学基金资助项目(04300395)

关键词子宫内膜异位症基质金属蛋白酶(MMP-7) 基质金属蛋白酶的组织抑制因子(TIMP-1) 中医药治疗

分类号 R271.911.71 [医药卫生—中西医结合]

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