摘要
３个月龄ＳＤ雌性大鼠６４只，双侧卵巢切除（ＯＶＸ）及行假手术（Ｓｈａｍ－Ｏ）；于术后第１，３，５，７个月各处死８只动物，切取Ｌ１～Ｌ２椎体节段，股骨及胫骨，进行ＢＭＤ检测结果ＯＶＸ后第１个月椎体ＢＭＤ明显丢失（Ｐ＜００１），全股骨丢失较为缓慢，７月时ＢＭＤ丢失才有差异（Ｐ＜００５）而股骨近段ＢＭＤ则自３月时丢失即有差异性（Ｐ＜００５）全胫骨１月ＢＭＤ即有差异性（Ｐ＜００５），３月时ＢＭＤ有回升（Ｐ＜００５），继之持续丢失，上段松质骨区则呈持续丢失结果提示：鼠ＯＶＸ后ＢＭＤ的丢失速度为腰椎＞胫骨＞股骨；
In 64 SD female rats aged 3 month, either bilateral ovariectomy (OVX) or sham surgery was performed. After the operation 8 rats were sacrificed respectively at the 1th, 3rd, 5th and 7th month. Bones were taken from the vertebrae, femur and tibia for the examination of bone mineral density (BMD). Result: In the 1st month after OVX, BMD disappeared apparently in the vertebrae (P<0.01) but slowly in the whole femur, whose BMD loss was not significantly different (P<0.05) until the 7th month; the proximal fumer lost BMD evidently (P<0.05) in the 3rd month; the whole tibia revealed, in the 1st month, a markedly different drop (P<0.05) in BMD, which went up (P>0.05) in the 3rd month but later continued to drop, with a consistent loss at the upper part of the osteoporosis region. Resultant suggestion: After the OVX in rats, BMD loss speed could be described as vertebrae > tibia >fumer; or as the lumbar vertebrae > the upper part of tibia > the upper part of fumer.
出处
《昆明医学院学报》
1997年第4期14-17,共4页
Journal of Kunming Medical College
基金
上海市政府九五攻关课题
关键词
卵巢切除
DEXA
骨密度
鼠
骨质疏松
Ovariectomy,DEXA,Bone mineral density (BMD),Vertebrae,Femur,Tibia,Rat
