摘要
对５２例胃肠道恶性肿瘤病人进行根治手术前后血清ＳＩＬ－２Ｒ水平表达的动态研究，并与４２例健康人对照比较结果显示：（１）胃肠道恶性肿瘤病人术前血清ＳＩＬ－２Ｒ水平为（４７８８５±１４１８８）Ｕ／ｍＬ，健康人对照组为（２５６４３±５９２９）Ｕ／ｍＬ，胃肠道恶性肿瘤病人术前血清ＳＩＬ－２Ｒ水平明显高于健康对照组（Ｐ＜００１）；（２）根治术后１０ｄ测定患者血清ＳＩＬ－２Ｒ水平为（２３１８２±１３９８９）Ｕ／ｍＬ，与手术前相比较，明显降低（Ｐ＜００１）结论：胃肠道恶性肿瘤病人机体细胞免疫功能在荷瘤状态时低下，出现免疫抑制物ＳＩＬ－２Ｒ水平明显增高的异常现象；根治手术切除肿瘤及转移淋巴结后，ＳＩＬ－２Ｒ水平明显降低提示：动态检测ＳＩＬ－２Ｒ水平是胃肠道恶性肿瘤病人病情监测。
In 51 cases of malignant gastroenteric tumor, serum SIL-2R-level expressions were studied dynamically and compared with those of 42-case normal subjects both before and after the radical operation. The results were shown as follows: 1) Before the operation the serum SIL-2R-level expression was significantly higher (P<0.01) in the patient group (478.85±141.88 U/mL) than in the control group (256.43±59.29 U/mL; 2) 10 days after the operation, the determined serum SIL-2R level (231.82±139.89 U/mL) evidently dropped as compared with that before the operation. Conclusion: The cellular immunologic function in malignant gastroenteric tumor patients was low under the tumor-attaching condition, accompanied by the abnormal phenomenon of rising SIL-2R level; after the radical removal of tumor and the metastasis of lymph node, SIL-2R level went down obviously. Suggestion: Dynamic test of SIL-2R level can be regarded as a reference indicator for monitoring the illness state and evaluating the curative response on the part of patients with malignant gastrenteric tumor.
出处
《昆明医学院学报》
1997年第4期47-49,共3页
Journal of Kunming Medical College
