摘要
应用核酸分子杂交技术检测了34例乳腺癌以及相应癌旁正常乳腺组织中肿瘤转移抑制基因nm23-H1等位基因缺失情况，分析该基因的等位基因缺失与肿瘤大小，发病年龄，雌激素受体状况以及腋下淋巴结转移之间的关系。结果发现nm23-H1等位基因缺失与肿瘤大小．发病年龄以及雌激素受体状况无关．而与腋下淋巴结转移关系十分密切．有转移病例nm23-H1等位基因缺失的百分率为333％（7／21）．无转移病例等位基因缺失的百分率为77％（1／13），两组病例对比差异有显著性（P＜0．05）。研究结果提示nm23-H1基因在抑制肿瘤转移方面具有重要作用。
Using Southern blot and immunohistochemical stain metheds we studied the allelic deletion of nm23-H1 gene in 34 cases ofbre3st cancer and corresponding normal breast tissues. The correlations between the allelic deletion of nm23-H1 gene and axillary lymph nede metastasis, tumor diameter. patient's age and estrogen receptor status were investigated. The results shown that eightcases of breast cancer have nm23-H1 gene allelic deletion. The nm23-H1 allelic deletion tate was 33. 3% (7/21) in axillary lymphnede metastasis grouP and 7. 7% (1/13) in the group without axillary lymph nede metastasis. There were cIose correIation be-tween allelic deletion of nm23-H1 and axillary lymph nede metastasis(P＜0. 05). No correlation between patient's age, tumor di-ameter.estrogen receptor status and the allelic deletion were found. The results suggest that nm23-H1 gene play an important rolein control the metastasis of breast cancer.
出处
《实用肿瘤杂志》
CAS
北大核心
1997年第6期257-259,共3页
Journal of Practical Oncology
