摘要
目的通过靶控输注不同浓度瑞芬太尼,研究其对脑电双频指数(BIS)的影响。方法美国麻醉学会手术前分级标准原则(ASA)Ⅰ~Ⅱ级择期全麻手术患者60例,随机分为3组(n=20)。瑞芬太尼靶控输注(TCI)靶浓度2.0ng/ml(Ⅰ组),4.0ng/ml(Ⅰ组),6,0ng/ml(Ⅲ组),记录给药前和达到预设效应室浓度1min后的心率(HR),平均动脉压(MAP),氧饱和度(SpO2),BIS和镇静警醒(OAA/S)评分。结果与给药前相比,靶控输注瑞芬太尼后,Ⅱ组Ⅲ组BIS降低明显(P〈0.05或P〈0.01),Ⅲ组OAA/S评分降低明显(P〈0,05)。与Ⅰ组相比较,Ⅱ组的BIS值降低有显著性差异(P〈0,05),Ⅲ组BIS值和OAA/S评分降低均有显著性差异(P〈0.05)。结论 瑞芬太尼靶浓度与BIS值呈负相关性,与OAA/S评分相比,BIS监测瑞芬太尼镇静效果更敏感与准确。
Objective To explore effect of target - controlled remifentanil infusion on bispectral index. Mehods 60 cases, ASA Ⅰ - Ⅱ underwent elective operation were randomly individed into Ⅰ , Ⅱ and Ⅲ groups according remifentanil infusion (target concentration of 2.0 ng/ml,4.0 ng/ml and 6.0 ng/mg) . During remifentanil administration, BIS values, OAA/S score,MAP, HR and SPO2 were recorded. Results Ⅰ group had no significant decreased BIS( P 〉 0.05 ). BIS in Ⅱ group and Ⅲ group decresed significantly ( P 〈0.05, P 〈 0.01 ). OAA/S score of Ⅰ and Ⅱ group was not changed ( P 〉 0.05 ) , while of Ⅲ group decreased ( P 〈 0.05 ). Conclusion Remifentanil infusion decreases BIS dose - dependently.
出处
《临床和实验医学杂志》
2008年第5期16-17,共2页
Journal of Clinical and Experimental Medicine
基金
深圳市科技信息局科技计划项目资助编号:200702121
关键词
脑电双频指数
瑞芬太尼
清醒镇静
靶控输注
Bispectral index
Remifentanil
Conscious sedation
Target - controlled infusion