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黄芪对血液透析患者氧化应激的影响 被引量:29

Effects of Astragalous Injection on oxidative stress status in maintenance hemodialysis patients
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摘要 目的:了解维持性血液透析(maintenance hemodialysis,MHD)患者的氧化应激及微炎症状态,观察黄芪对其的影响。方法:选取60例MHD患者随机分为2组,在透析过程中给予(治疗组)或不予(对照组)黄芪注射液治疗12周,另选取年龄和性别匹配的健康成年志愿者10例为健康人组。荧光分光光度法测定血浆晚期糖基化终末产物(advanced glycation end products,AGEs)、晚期蛋白质氧化产物(advanced oxidation proteinproduct,AOPP)、脂氧化终末产物丙二醛(malondialdehyde,MDA)及维生素E(vitamin E,Vit E)含量;酶联免疫吸附法(enzyme-linked i mmunosorbent assay,ELISA)测定血浆C反应蛋白(C-reactive protein,CRP)含量。结果:与健康人比较,MHD患者血浆AGEs、AOPP、MDA和CRP含量显著升高(P<0.01),Vit E含量显著降低(P<0.01);黄芪注射液治疗12周后,MHD患者血浆AGEs、AOPP、MDA和CRP含量明显下降(P<0.05,P<0.01),Vit E浓度无变化(P>0.05)。结论:MHD患者存在明显的氧化应激及微炎症状态;黄芪注射液可在一定程度上降低其氧化产物的蓄积,减轻微炎症状态,但减少抗氧化剂Vit E丢失的作用不明显。 Objective: To analyze the effects of Astragalous Injection on oxidative stress and micro-inflammatory status in patients undergoing maintenance hemodialysis (MHD). Methods: Sixty MHD patients were included and randomized into treatment group and control group, with another 10 healthy volunteers as normal control. The patients in the treatment group were treated with Astragalous Injection and the patients in the control group were treated with normal saline for 12 weeks. A spectrophotometric method was used for the measurement of plasma concentrations of oxidative parameters including advanced glycation end products (AGEs), advanced oxidation protein product (AOPP), malondialdehyde (ME)A) and vitamin E (Vit E). The content of C-reactive protein (CRP) was evaluated by enzyme-linked immunosorbent assay. Results: Compared with the normal control group, the plasma levels of AGEs, AOPP, MDA and CRP were significantly increased, while plasma level of Vit E was significantly decreased in MHD patients ( P〈0.01). After Astragalous Injection treatment, the plasma levels of AGEs, AOPP, MDA and CRP were decreased as compared with the control group ( P〈0.01), while there was no significant difference in plasma Vit E level between the treatment group and control group. Conclusion: There exist oxidative stress and micro-inflammation in MHD patients. Astragalous Injection can ameliorate the accumulation of oxidative products and micro-inflammatory status, but it has no significant effect on plasma Vit E level.
出处 《中西医结合学报》 CAS 2008年第5期468-472,共5页 Journal of Chinese Integrative Medicine
基金 上海市浦东新区科技发展基金资助项目(NoPKJ2005-35)
关键词 黄芪 血液透析 氧化性应激 Astragalous membranaceus hemodialysis oxidative stress
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参考文献20

  • 1刘志强,侯凡凡,王力,舒友梅.ELISA法检测人血清晚期糖基化终产物及在血液透析病人的应用[J].解放军医学杂志,2000,25(6):391-393. 被引量:12
  • 2Witko-Sarsat V, Friedlander M, Nguyen Khoa T, et al. Advanced oxidation protein products as novel media- tors of inflammation and monocyte activation in chronic renal failure. J Immunol. 1998~ 161(5) : 2524-2532.
  • 3龚德华,季大玺.终末期肾脏病患者的透析治疗现状[J].肾脏病与透析肾移植杂志,1999,8(1):74-77. 被引量:70
  • 4Axelsson J, Heimburger O, Stenvinkel P. Adipose tissue and inflammation in chronic kidney disease. Contrib Nephrol. 2006; 151: 165-174.
  • 5Cottone S, Palermo A, Vaccaro F, et al. Oxidative stress and inflammation in long-term renal transplanted hypertensives. Clin Nephrol. 2006.66(1): 32-38.
  • 6Ben-Zvi I, Green Y, Nakhoul F, et al. Effects of diabetes mellitus, chronic renal failure and hemodialysis on serum and salivary antioxidant status. Nephron Clin Pract. 2007; 105(3): 114-120.
  • 7Bergstrom J, Lindholm B, Lacson E Jr, et al. What are the causes and consequences of the chronic inflammatory state in chronic dialysis patients? Semin Dial. 2000; 13 (3) : 163-175.
  • 8Kaysen GA. The microinflammatory state in uremia: causes and potential consequences. J Am Soc Nephrol.2001; 12(7): 1549-1557.
  • 9Panichi V, Migliori M, De Pietro S, et al. C-reactive protein as a marker of chronic inflammation in uremic patients. Blood Purif. 2000; 18(3): 183-190.
  • 10王质刚.维持性血液透析患者感染并发症[J].中国血液净化,2003,2(10):524-526. 被引量:41

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