摘要
目的:观察复方苦参含漱液治疗糜烂型扁平苔藓的临床疗效,以及治疗前、后患者口腔内细菌的检出量、检出率及构成比的变化。方法:采用复方苦参含漱液治疗糜烂型扁平苔藓患者30例,采用SAS6.12软件包中的配对t检验比较用药前、后患者疼痛指数的变化,实验室检查治疗前、后患者口腔唾液细菌检出量、检出率和构成比的变化。对细菌检出率、构成比进行χ2检验,处于非正态分布的细菌检出量,取其常用对数值进行非参数相关检验。结果:用药1周后,患者疼痛指数显著下降(P<0.01)。糜烂型扁平苔藓患者口腔内细菌总检出率、检出量减少。葡萄球菌的检出量显著减少(P<0.05);其他唾液细菌的检出率和检出量虽有减少,但无统计学意义。细菌构成比无显著性差异。结论:复方苦参含漱液对口腔糜烂型扁平苔藓患者唾液葡萄球菌有抑制作用,是一种局部治疗口腔扁平苔藓的有效药物,可作为全身用药的辅助治疗。
PURPOSE： To evaluate the effect of compound light yellow Sophora root collutory on oral erosive lichen planus and analyze the salivary microbial contents and proportion. METHODS： 30 patients with oral erosive lichen planus were chosen and treated with compound light yellow Sophora root collutory. Pain index and clinical symptoms were observed, the changes of quantity and proportion of salivary bacteria were investigated before and after taking drugs. SAS6.12 software package was used for statistical analysis. RESULTS： The extravasate and congest of the erosive mucous membrane were relieved. The pain caused by erosion were significantly relieved after taking the drugs. The quantity of oral Staphylococcus was significantly decreased after taking the drugs. CONCLUSIONS： Oral Staphylococcus can be inhibited by light yellow Sophora root collutory. The use of compound light yellow Sophora root collutory is one of the safe and effective local therapies on oral lichen planus. Supported by Research Fund of Science and Technology Committee of Shanghai Municipality（Grant No.034119924）.
出处
《上海口腔医学》
CAS
CSCD
2008年第2期118-120,共3页
Shanghai Journal of Stomatology
基金
上海市科学技术委员会科研计划项目(034119924)
关键词
复方苦参含漱液
扁平苔藓
口腔菌群
Compound light yellow Sophora root collutory
Oral lichen planus
Microflora
Bacteria
