摘要
目的:探讨心功能不全患者血清尿酸水平的变化规律及其临床意义。方法:比较76例心功能不全患者与42例健康对照组的血清尿酸水平;比较心功能不全患者在不同心功能状态下的血清尿酸水平;比较68例患者心衰控制前、后血清尿酸水平的变化;比较入院时未用过利尿剂与已用过利尿剂的心衰患者的血清尿酸水平。结果:心功能不全组与健康对照组的血清尿酸水平分别为(492.34±34.67)μmol/L和(257.02±25.21)μmol/L,两者之间差异有统计学意义(P<0.05);心功能不全组心功能分级Ⅱ、Ⅲ、Ⅳ级的血尿酸水平分别为(349.24±25.40)μmol/L、(451.12±23.12)μmol/L和(557.27±24.61)μmol/L,不同心功能组比较,差异有显著性意义(P<0.05);68例患者心衰控制前、后的血清尿酸水平分别是(512.34±21.32)μmol/L和(403.13±24.35)μmol/L,前后差异有统计学意义(P<0.05);未用过利尿剂与已用过利尿剂的心衰患者的血清尿酸水平差异无统计学意义(P>0.05)。结论:心功能不全患者血清尿酸水平随心功能加重而升高,血清尿酸水平不受服用利尿剂的影响。血清尿酸水平是反映心衰患者病情严重程度的一个指标。
Objective：To assess the clinical significance of increased serum uric acid level in patients with congestive heartfailure Methods： The objects of this study consisted of 76 patients with CHF and 42 healthy subjects as controls. The serum uric acidlevels were compared in the 76 patients with CHF and 42controls; 76 patients with different severity of heart failure; patients with and without diuretic therapy; uric acid level of 68 CHF patients before and after the improvement of heart failure Results： The concentration of serum uric acid in CHF patients and controls was（492. 34±34. 67）μmol/L and （257.02±25. 21） μmol/L, respectively（P〈0. 05）. The concentration of serum uric acid in patients NYHA function class II, III, iV was （349. 24±25. 40）μmol/ L, （451.12±23. 12） μmol/ L and （557. 27±24. 61）μmol/L,respectively（P〈0.05）. Serum acid level was （512. 34±21.32） μmol/L and （403. 13±24. 35）μmol/ L before and after improvement of heart failure（P〈0. 05）. There was no difference between the patients who had diuretics and who had not. Condusion： The serum uric acid level increases in patients with CHF. It is associated with deterioration of heart failure and independent of diurtics therapy. It is a predictor of the severity of heart failure.
出处
《医学理论与实践》
2008年第5期497-499,共3页
The Journal of Medical Theory and Practice
关键词
心功能不全
尿酸
利尿剂
Heart failure, Uric acid, Diuretic
