摘要
目的:研究去甲氧基姜黄素对姜黄素稳定性的影响,揭示中药姜黄中存在着对姜黄素产生稳定作用的天然稳定剂。方法:以pH=8的缓冲溶液为反应介质,将去甲氧基姜黄素定量加入到姜黄素中,高效液相色谱法测定姜黄素浓度的变化,采用动力学方法建立姜黄素降解速率方程。结果:去甲氧基姜黄素、姜黄醇提取物都有助于姜黄素半衰期延长,且随着加入量的增加,姜黄素降解半衰期延长。结论:去甲氧基姜黄素在中药姜黄中对姜黄素产生稳定作用,为姜黄素天然稳定剂,在研制姜黄素制剂时,加入去甲氧基姜黄素或姜黄醇提取物,可提高姜黄素的稳定性。
Objective： To investigate effect of demethoxycurcumin on stability of curcumin. Methods：To add the demethoxycurcumin to pure curcumin, the change of curcumin was determined by HPLC and the dynamics of curcumin degradation was investigated. Result：The stability both obtained from alcohol and demethoxycurcumin improved the stabilization of curcumin, the demiperiod of curcumin prolonged with the addition of demethoxycurcumin. Conclusion： The commixture of curcumin and demethoxycurcumin are more stable than pure curcumin at thesame conditions. Stability of curcumin is improved by demethoxycurcumin, it is crude stabilizing agent.
出处
《中药材》
CAS
CSCD
北大核心
2008年第4期592-594,共3页
Journal of Chinese Medicinal Materials
