摘要
目的:通过比较口底鳞癌原发灶切除同时行非连续性和连续性颈淋巴结清除的疗效,探讨口底鳞癌颈淋巴结清除的合理方式。方法:回顾性分析67例行非连续性与连续性颈淋巴结清除的口底鳞癌患者的临床资料,比较两组病例的生存率和复发率。结果:非连续性颈淋巴结清除组与连续性颈淋巴结清除组相比,Ⅰ、Ⅱ期或cN0,两组病例的生存曲线差异均无统计学意义,LogRank统计值分别为1.295和1.527,P值分别为0.255和0.217;Ⅲ、Ⅳ期或cN1～cN2,连续性清除组较非连续清除组5年累积生存率高,LogRank统计值分别为7.692和8.737,P值分别为0.006和0.003。行连续性颈淋巴结清除后原发灶及Ⅰ区复发率较非连续颈淋巴结清除低,χ2=11.995,P=0.001。结论:口底鳞癌连续性颈淋巴结清除较非连续颈淋巴结清除疗效好。
OBJECTIVE： To clarify the curative effect of squamous cell carcinoma of the floor of mouth between non-continuous and continuous neck dissection. METHODS： Retrospectively 67 cases of squamous cell of the floor of mouth that underwent non-continuous neck dissection or continuous neck dissection, the survival rate and the recurrent rate were compared. RESULTS： In the early cases （ Ⅰ ＋ Ⅱ or cN0） , the differences of survival rate between the two groups were insignificant （P were 0. 255 and 0. 217, respectively） . But in advanced cases （Ⅲ ＋ Ⅳ or CN1-~ cN2 ）, there was higher 5-year cumulative survival rate in continuous dissection group （P were 0. 006 and 0. 003 respectively） . There was no significance of overall recurrence rate between two groups （P = 0. 102）. In continuous dissection group there were less recurrence cases in primary lesion and in lymph nodes of level Ⅰ than non-continuous group （P = 0. 001 ）. CONCLUSION： The curative effect of continuous neck dissection is better than non-continuous neck dissection in squamous cell carcinoma of the floor of mouth.
出处
《中华肿瘤防治杂志》
CAS
2008年第8期621-623,638,共4页
Chinese Journal of Cancer Prevention and Treatment
