摘要
由胰岛β细胞功能失调,导致胰岛素分泌的相对或绝对的缺失,进而出现高血糖症状,是糖尿病的重要发病机制。目前认为糖尿病的发病与机体的炎症过程密切相关。作为炎症过程的重要调节因子白细胞介素-1β(IL-1β),通过激活MAPK、NFκB、PKC等信号通路,最终导致β细胞功能失调是糖尿病发生发展的重要原因。IL-1β在介导糖尿病的β细胞功能失调中发挥核心作用。
Pancreatic islet β-cell dysfunction occurs in diabetes mellitus, leading to absolute or relative insulin deficiency, thus causing hyperglycemia. Recent studies show that there is a close relationship between diabetes mellitus and inflammation. Intra-islet inflammatory mediators seem to trigger a final pathway leading to β- cell death in diabetes. Interleukin-1β is a potent inflammatory cytokine, which plays a central role in β-cell dysfunction in diabetes mellitus via activating MAPK, NFκB or PKC signal pathway.
出处
《细胞生物学杂志》
CSCD
2008年第2期166-170,共5页
Chinese Journal of Cell Biology
基金
上海市浦江人才支持计划(No.05PJ14073)资助~~
