摘要
为了证实肾脏接受体外冲击波碎石术（ESWL）时可能产生氧自由基脂质过氧化反应而发生急性肾功能损害，采用硫代巴比妥酸法和放射免疫分析法分别测定了血清及尿液中氧自由基代谢产物丙二醛（MDA）和血清超氧化物歧化酶（SOD），结果发现肾结石患者外周血和山羊肾组织匀浆在ESWL后MDA浓度明显升高，SOD活力明显下降。认为行ESWL时肾脏产生大量氧自由基，抗氧化能力缺乏，脂质过氧化作用加剧是导致ESWL后肾功能损害的重要机理之一，并据此提出了肾功能损害的预防措施。
To prove kidney underwent extracorporeal shock wave lithotripsy (ESWL) would produce impairment of renal function because of production of oxygen free redicals and lipid peroxidation reaction. The level of lipid peroxidation product - malonydehyde in serum and urine we re deterhaned using thiobarbituric acid and the serum level of superoside dismutas were determned using radiommunoassay. It is suggested that the content of lipid peroxidation product -malonyldehyde (MDA) increased,but activities of superoside decreased markedly in the peripheral venous blood of renal stone patients and sheep kidney tissues after ESWL. The results revealed that the production of oxygen free redicals,deficiency of antioxidation enzymes activity and exacerbation of lipid perosidation reaction may be an important mechanism of renal function damage by ESWL.
出处
《临床泌尿外科杂志》
1997年第6期355-357,366,共4页
Journal of Clinical Urology
关键词
体外冲击波
碎石术
氧自由基
肾功能损害
Extracorporeal shock wave lithotripsy Oxygen free radical Impairment of renal function
