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Wnt signaling and stem cell control 被引量:30

Wnt signaling and stem cell control
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摘要 Wnt signaling has been implicated in the control over various types of stem cells and may act as a niche factor to maintain stem cells in a self-renewing state. As currently understood, Wnt proteins bind to receptors of the Frizzled and LRP families on the cell surface. Through several cytoplasmic relay components, the signal is transduced to β-catenin, which then enters the nucleus and forms a complex with TCF to activate transcription of Wnt target genes. Wnts can also signal through tyrosine kinase receptors, in particular the ROR and RYK receptors, leading to alternative modes of Wnt signaling. During the growth of tissues, these ligands and receptors are dynamically expressed, often transcriptionally controlled by Wnt signals themselves, to ensure the right balance between proliferation and differentiation. Isolated Wnt proteins are active on a variety of stem cells, including neural, mammary and embryonic stem cells. In general, Wnt proteins act to maintain the undifferentiated state of stem cells, while other growth factors instruct the cells to proliferate. These other factors include FGF and EGF, signaling through tyrosine kinase pathways.
作者 Roel Nusse
出处 《Cell Research》 SCIE CAS CSCD 2008年第5期523-527,共5页 细胞研究(英文版)
关键词 WNT stem cells SELF-RENEWAL signal transduction NICHE 细胞科学 干细胞 信号转换 小生境
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  • 1Korinek V, Barker N, Moerer P, et al. Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4. Nat Genet 1998, 19:379-383.
  • 2Reya T, Duncan AW, Ailles L, et al. A role for Wnt signalling in self-renewal of haematopoietic stem cells. Nature 2003; 423:409- 414.
  • 3Willert K, Brown JD, Danenberg E, et al. Wnt proteins are lipidmodified and can act as stem cell growth factors. Nature 2003; 423:448-452.
  • 4Bienz M, Clevers H. Linking colorectal cancer to Wnt signaling. Cell 2000; 103:311-320.
  • 5Jamieson CH, Ailles LE, Dylla S J, et al. Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML. N Engl J Med 2004; 351:657-667.
  • 6Logan CY, Nusse R. The Wnt signaling pathway in development and disease. Annu Rev Cell Dev Biol2004; 20:781-810.
  • 7Nusse R, Varmus HE. Wnt genes. Cell 1992; 69:1073-1087.
  • 8Miller JR. The Wnts. Genome Biol2002; 3:REVIEWS3001.
  • 9Mason JO, Kitajewski J, Varmus HE. Mutational analysis of mouse Wnt-1 identifies two temperature-sensitive alleles and attributes of Wnt-1 protein essential for transformation of a mammary cell line. Mol Biol Cell 1992; 3:521-533.
  • 10Reichsman F, Smith L, Cumberledge S. Glycosaminoglycans can modulate extracellular localization of the wingless protein and promote signal transduction. J Cell Biol 1996; 135:819-827.

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