摘要
目的观察痰瘀同治法对动脉粥样硬化(AS)家兔血脂、组织型纤溶酶原激活物(t-PA)与纤溶酶原激活物抑制剂(PAI)、血小板聚集性及血液流变学的影响。方法将50只家兔随机分为5组,每组10只。分别为空白对照组、模型组、地奥心血康组(0.02g/kg)、痰瘀同治方大、小剂量组(7.5g/kg,15g/kg)。除空白对照组外其余各组给予高脂饲料喂养后4周开始灌胃给药,每日1次,连续4周后处死动物,测定血脂、t-PA与PAI、血小板黏附与聚集性及血液流变学相关指标。结果痰瘀同治方大、小剂量组能显著改善AS家兔血脂变化,升高t-PA并降低PAI,抑制血小板第1分钟聚集率及最大聚集率,降低全血高切变率及低切变率黏度、全血还原黏度、血小板黏附率与血沉。结论痰瘀同治法可通过改善血脂异常,提高纤溶活性,抑制血小板聚集,改善微循环等方面来防治AS。
Objective To study the effects of simultaneous treatment of phlegm and stasis on the changes of blood fat, tissue plas- minogen activator （t-PA） and plasminogen activator inhibitor （PAI）, platelet agglutinate rate and hemorheology in atherosclrotic rabbits. Methods The 50 white rabbits were divided randomly into five groups with 10 in each： blank control group, model group, Di＇ao Xinxuekang （0. 02g/kg） group, phlegm and stasis simultaneous treatment small and large dose （7. 5g/kg, 15g/kg） groups. After four weeks＇ high-fat feedstuff feed, the rabbits were given medicine gavage per day for 4 weeks and then killed. The blood fat, t-PA and PAI, platelet agglutinate rate and hemorheology were measured. Results The phlegm and stasis simultaneous treatment in the treated group could significantly improve the level of blood fat, increase t-PA and decrease PAI, significantly inhibit the platelet one minute agglutinate rate and maximum agglutinate rate, significantly decrease the whole blood high cut rate and low cut rate viscosity, whole blood revert viscosity, platelet adhesion, and erythrocyte sedimentation rate （ESR） in atherosclerosis （AS） rabbit. Conclusion Simultaneous treatment of phlegm and stasis can prevent AS through improving abnormal blood fat, increasing fibrinolytic activity, inhibiting platelet aggregation, and improving microcircularion.
出处
《中医杂志》
CSCD
北大核心
2008年第4期349-352,共4页
Journal of Traditional Chinese Medicine
基金
国家自然科学基金资助项目(30170371,30570732)
关键词
痰瘀同治
动脉粥样硬化
凝血
纤溶活性
血小板聚集性
血液流变学
Simultaneous treatment of phlegm and stasis~ Atherosclerosis~ Blood coagulation
Fibrinolytic activity
Platelet aggrega-tion
Hemorheology
