摘要
"氯吡格雷抵抗"是心血管领域近年来使用越来越多的一个术语,用来描述服用氯吡格雷后在血小板功能抑制方面未能达到预期作用的现象。研究表明,氯吡格雷抵抗可能与血栓事件的反复发生及亚急性支架内血栓的形成有重要关系。氯吡格雷抵抗可能受多方面因素的影响,包括外部因素和内部因素。迄今为止,其确切机制尚未完全阐明。现就目前有关氯吡格雷抵抗的研究证据作一综述。
Clopidogrel resistance is a widely used term that is not yet clearly defined. Up to now,it has been used to describe the failure of clopidogrel to achieve its anti-aggregatory effect ,or a clinical entity with potentially severe consequences such as recurrent myocardial infarction ,stroke or death. The mechanism of resistance is multifactorial. It can be due to extrinsic or intrinsic mechanisms. Presently ,the best laboratory procedure to screen for possible clopidogrel variability of response remains to be determined. This article discusses currently available evidence surrounding the variability in the anti-platelet response to clopidogrel.
出处
《心血管病学进展》
CAS
2008年第3期419-422,共4页
Advances in Cardiovascular Diseases
关键词
氯吡格雷
氯吡格雷抵抗
血小板聚集
clopidogrel
clopidogrel resistance
platelet aggregation
