摘要
目的 观察奥沙利铂联合希罗达治疗晚期结肠癌的临床疗效和毒副反应。方法 30例晚期结肠癌患者应用奥沙利铂130mg／m^2，静滴3h，d，；希罗达1250mg／m^2，bid，口服，d．～14；21d为1周期，2周期以上评价疗效。结果 30例均可评价疗效，CR2例，PR15例，RR56．7％；毒副反应主要为Ⅰ～Ⅱ度恶心、呕吐，口腔溃疡，腹泻，末梢神经异常及骨髓抑制。结论 奥沙利铂联合希罗达治疗晚期结肠癌疗效确切，耐受性好，值得临床推广应用。
Objective To investigate the efficacy and tolerability of oxaliplatin combined with xeloda in advanced colon cancer. Methods 30 patients with advanced colon cancer were treated with oxaliplatin 130 mg/m^2 ivgtt d1 and xeloda 1 250 mg/m^2 po d1-14. 21 days was one cycle. The effect was evaluated after two cycles. Results Two cases were complete response and fifteen cases were partial response. The overall response rate was 56.7% . Adverse effects were mainly grade Ⅰ - Ⅱ ; including nausea, vomiting, diarrhea, mouth ulcer, peripheral neuritis and marrow inhibition. Conclusions Oxaliplatin combined with xeloda regimen is an effective and better tolerated treatment in advanced colon cancer and can yield promising clinical application.
出处
《肿瘤基础与临床》
2008年第3期232-233,共2页
journal of basic and clinical oncology
关键词
奥沙利铂
希罗达
联合化疗
晚期结肠癌
oxaliplatin
xeloda
combination chemotherapy
advanced colon cancer
