摘要
目的:对肝移植患者术后抑郁状态进行相关资料评估,分析相关因素,寻找提高患者术后生活质量的有效方案。方法:综合近年肝移植患者术后精神状态分析相关文献并结合解放军第四五一医院普外科接受肝移植、并有完整临床资料的20例患者术后的心理状态,应用Zung抑郁自评量表和Hamilton抑郁量表对术后患者进行常规筛选评估,对诊断为抑郁状态的患者应用盐酸舍曲林50mg/d连续治疗5周,并进行心理疏导、人为关怀。结果:①20例患者中,6例抑郁自评量表的粗分>40分,检出阳性率为33.3%。Zung抑郁自评量表阳性者汉密顿抑郁量表评分均>14分。其中>24分者2例,占受检的10%。6例Zung抑郁自评量表评定阳性患者中4例得分<56分,为轻度抑郁,2例得分>56分,为中度抑郁。②治疗前Zung抑郁自评量表的平均得分为47.62分,汉密顿抑郁量表评分为20.31分,治疗后5周Zung抑郁自评量表的得分为平均32.23分,汉密顿抑郁量表得分为8.97分,与治疗前比较,差异有显著性意义(P<0.01)。③经过抗抑郁治疗后,临床症状改善明显,生活质量评分显著升高。结论:肝移植患者术后抑郁状态明显,在此期间加强心理干预并以抗抑郁药物治疗,对可提高肝移植患者术后生活质量并对其预后产生积极的影响。
AIM： To evaluate the data of depression status of patients after liver transplantation, and analyze the related factors to find an effective protocol to improve quality of life of patients after transplantation. METHODS： According to the articles about the mental condition of patients after liver transplantation in recent years and the mental status of 20 patients undergoing liver transplantation in Department of General Surgery, the 451 Hospital of Chinese PLA with complete clinical data, the patients were evaluated using Zung Self-rating Depression Scale （SDS） and Hamilton Depression Scale （HAMD）. Patients who diagnosed to depression were treated with Sertraline Hydrochloride （50 mg/d） for successive 5 weeks in combination with psychological guidance and social support. RESULTS： Of 20 patients, 6 cases scored 〉 40 for SDS, and the positive rate was 33.3%. Patients positive in SDS scored 〉 14 for HAM, of which 2 cases （10%） scored 〉 24. Of 6 patients positive in SDS, 4 cases scored 〈 56 as mild depression and 2 scored 〉 56 as moderate depression. Mean score was 47.62 for SDS, and 20.31 for HAM before treatment, and 32.23 for SDS, and 8.97 for HAM after 5 weeks of treatment. The differences were statistically significant （P 〈 0.01）. Anti-depression treatment significantly improved clinical symptoms and scored for quality of life. CONCLUSION： Depression is obvious in patients after liver transplantation. Psychological intervention and anti-depressant drug therapy can improve their quality of life and positively influence the prognosis.
出处
《中国组织工程研究与临床康复》
CAS
CSCD
北大核心
2008年第18期3523-3526,共4页
Journal of Clinical Rehabilitative Tissue Engineering Research
