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氯胺酮在神经病理性疼痛治疗中的作用及治疗进展——根据病例报道的综述 被引量:1

Role of ketamine in neuropathic pain relief and its treatment progress: a case-based review
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摘要 持续存在的有害刺激常可导致中枢痛觉致敏作用,这种作用可使某种强度不大的刺激引起机体感知到强烈的疼痛。N-甲基-D-天冬氨酸受体(NMDA受体1导致的致敏作用就是通过脊髓后角处的某些改变来引起痛觉高敏的,相反。NMDA受体拮抗剂(包括氯胺酮和美沙酮等)可以减弱中枢致敏作用,从而缓解神经性疼痛。我们结合Okon报道的一例典型的神经病理性疼痛患者的诊疗过程,对氯胺酮在神经病理性疼痛治疗中的作用及治疗进展做一综述。
作者 龚政 刘树孝
出处 《中华神经医学杂志》 CAS CSCD 2008年第5期538-540,共3页 Chinese Journal of Neuromedicine
关键词 神经病理性疼痛 氯胺酮 Neuropathic pain Ketamine
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