1Jiang R,Zatta A,Kin H,et al. PAR-2 activation at the time of reperfusion salvages myocardium via an ERK1/2 pathway in in vivo rat hearts[J]. Am J Physiol Heart Circ Physiol,2007,293 (5) : 2845-2852.
2Ramachandran R, Morice AH, Compton SJ. Proteinase-activated receptor 2 agonists upregulate granulocyte colony-stimulating factor, IL-8,and VCAM-1 expression in human bronchial fibroblasts[J]. Am J Respir Cell Mol Biol,2006,35(1 ): 133- 141.
3Qihai Gu, Lu-Yuan Lee. Hypersensitivity of pulmonary chemosensitive neurons induced by activation of protease-activated receptor-2 in rats[J]. J Physiol,2006,574(3) : 867-876.
4Dulon S, Leduc D, Cottrell GS, et al. Pseudomonas aeruginosa elastase disables proteinase-activated receptor 2 in respiratory epithelial cells[J]. Am J Respir Cell Mol Biol, 2005,32 (5): 411-419.
5Knecht W,Cottrell GS,Amadesi S,et al. Trypsin Ⅳ or mesotrypsin and p23 cleave protease-activated receptors 1 and 2 to induce inflammation and hyperalgesia[J]. J Biol Chem, 2007, 282(36) : 26089-26100.
6Cattaruzza F, Cenac N, Barocelli E, et al. Protective effect of proteinase-activated receptor-2 activation on motility impairment and tissue damage induced by intestinal ischemia/reperfusion in rodents [J]. Am J Pathol,2006,169(1): 177-188.
7Sharma A,Tao X, Gopal A, et al. Calcium dependence of proteinase-activated receptor 2 and cholecystokinin-mediated amylase secretion from pancreatic acini[J]. Am J Physiol Gastrointest Liver Physiol,2005,289(4) : 686-695.
8Misaki T,Satoh Y, Saino T, et al. The role of protease-activated receptors on the intracellular calcium ion dynamics of vascular smooth muscles,with special reference to cerebral arterioles[J]. Arch ytol Histol,2006,69(1) : 49-60.
9Caruso R, Pallone F, Fina D, et al. Protease-activated receptor- 2 activation in gastric cancer cells promotes epidermal growth factor receptor trans-activation and proliferation [J]. Am J Pathol, 2006,169 ( 1 ) : 268-278.
10Uusitalo-Jarvinen H, Kurokawa T, Mueller BM, et al. Role of protease activated receptor 1 and 2 signaling in hypoxia induced angiogenesis[J]. Arterioscler Thromb Vase Biol, 2007,27 (6) : 1456-1462.
5Koshikawa N, Hasegawa S, Nagashima Y, et al. Expression of trypsin by epithelial cells of various tissues, leukocytes, and neurons in human and mouse. Am J Pathol, 1998, 153: 937-944.
6Miyata S, Koshikawa N, Yasumitsu H, et al. Trypsin stimulates integrin alpha(5)beta( 1)-dependent adhesion to fibronectin and proliferation of human gastric carcinoma ceils through activation of proteinase-activated receptor-2. J Biol Chem, 2000, 275: 4592-4598.
7Darmoul D, Marie JC, Devaud H, et al. Initiation of human colon cancer cell proliferation by trypsin acting at protease-aetivated receptor-2. Br J Cancer, 2001, 85: 772-779.
8Darmoul D, Gratio V, Devaud H, et al. Protease-activated receptor 2 in colon cancer: trypsin-induced MAPK phosphorylation and cell proliferation are mediated by epidermal growth factor receptor transactivation. J Biol Chem, 2004, 279: 20927-20934.
9Shimamoto R, Sawada T, Uchima Y, et al. A role for protease-actirated receptor-2 in pancreatic cancer cell proliferation, hat J Oncol, 2004, 24: 1401-1406.
10Hedstr0m J, Haglund C, Haapiainen R, et al. Serum trypsinogen-2 and trypsin-2-alpha(1)-antitrypsin complex in malignant and benign digestive-tract diseases. Preferential elevation in patients with cholangiocarcinomas. Int J Cancer, 1996, 66: 326-331.
