摘要
目的:探讨胃癌β-连环蛋白(β-catenin)与尾侧型同源转录因子-2(CDX-2)的表达与浸润、转移及预后的关系.方法:胃癌患者80例,以正常胃黏膜12例作为对照,应用SP免疫组化方法检测β-catenin和CDX2的表达.结果:正常胃黏膜上皮中β-catenin全部正常表达,而在胃癌组织中表达减弱、缺失或分布异常.CDX2则在正常胃黏膜上皮中不表达.β-catenin和CDX2的表达与胃癌组织的分化程度、肿瘤生长方式、癌细胞浸润深度及淋巴结转移有关(P<0.01).当患者β-catenin阳性表达/CDX2阳性表达时,术后5 a生存率最高(P<0.05).结论:β-catenin,CDX2与胃癌的发生、浸润、转移有关.
AIM： To analyze the assoeiotion of the expression of β-catenin and CDX2 with invasion, metastasis, and prognosis of human gastric carcinoma. METHODS： Eighty patients with gastric carcinoma and 12 normals as control were examined for the expression of β-catenin and CDX2 by SP immunohistochemistry. RESULTS： β-catenin was present in all normal gastric mucomembranous epithelium, but CDX2 was not. β-catenin was decreased, deficient, or abnormally distributed in gastric carcinoma tissues. These two markers were associated with the differentiation, invasion, metastasis of gastric carcinoma（ P 〈 0.01 ）. The 5-year survival rate was highest in patients with co-expression of β-catenin and CDX2 （P 〈0.05 ）. CONCLUSION： The expression of CDX2 or β-catenin may be associated with the genesis, invasion, and metastasis of gastric carcinoma.
出处
《第四军医大学学报》
北大核心
2008年第10期936-938,共3页
Journal of the Fourth Military Medical University
