摘要
目的探讨复方甘草甜素与干扰素联用时对慢性乙型肝炎患者免疫功能及抗病毒结局的影响。方法选择符合诊断标准的HBeAg阳性慢性乙型肝炎患者60例，按配对方法平均分为治疗组和对照组，两组基本用药均为干扰素α-2b，治疗组在最初12周内联用复方甘草甜素片。治疗前及治疗过程中监测T淋巴细胞亚群、肝功能、血常规、乙肝六项、HBV—DNA及副反应等。结果治疗组从4周末免疫功能增强，8周〉4周〉0周，P均〈0.01；12周和8周相近，P〉0．05；对照组从8周末免疫功能增强，12周〉8周〉0周，P均〈0．01；4周、8周末时治疗组免疫功能优于对照组，P均〈0.05，12周无差别，P〉0．05。治疗组从第2周末ALT即有明显下降，4周、8周、12周末ALT复常率均高于对照组，P均〈0．05；对照组从8周末ALT才有明显下降。在4、8、12周末，治疗组症状明显或完全改善者比例均高于对照组，P均〈0．05。24周HBV—DNA阴转率及E抗原转换率比较，两组无统计学意义，P〉0．05。结论应用干扰素治疗慢性乙型肝炎时联用复方甘草甜素并不降低机体免疫功能，甚至在一定时间内尚能增强免疫功能，并且能较快改善症状使转氨酶复常，对干扰素的抗病毒结局无影响。
Objective To evaluate the influence of compound glycyrrhizin combined with interferon to the immunologic function and anti - HBV effect in the treatment of chronic hepatitis B. Methods Sixty HBeAg positive HBV patients were divided into study group （30 cases） and control group （30 cases） according to partnership method, two group patients were all injected with interferonα -2b as basal remedy, besides the medicament, the study group received compound glycyrrhizin tablets in initial 12 weeks. T - lymphocyte - subsetes, liver funtion,blood routine,6 HBV markers, HBV- DNA and side effects were determined and inspected before and after the treament. Results The study group＇ s immunologic function enhanced from the fourth weekend（8W 〉4W 〉 0W, P 〈 0.01 ）, was approximate on the eighth weekend and the twelfth weekend （ P 〉 0. 05） ;the control group＇s immunologic function enhanced from the eighth weekend （12W 〉 8W 〉 0W, P 〈 0. 01 ） ;the study group＇s immunologic function excelleded the control group＇s on the fourth and eighth weekend （ P 〈 0.05 ）, but no different on the twelvth weekend （ P 〉 0.05 ）. The ALT value descended obviously from the second weekend in study group,but from the 8th weekend in control group, and the recovery rate of ALT exceeded the control group＇ s on 4^th ,8^th and 12^th weekend （ P 〈 0.05）. The rate of symptoms improver obviously or completely exceeded the control group＇ s on 4^th ,8^th and 12^th weekend （ P 〈 0.05 ）. The rate of negative conversion of HBV - DNA and E - antigen conversion were not significantly different between two groups on 24^th weekend （ P 〉 0.05 ）. Conclusion Compound glycyrrhizin combined interferon don＇ t debase body immunologic function, even enhance immunologic function in certain time, furthermore, could improve symptom and make ALT recovery rapidly,have no influence on interferon＇ s anti -HBV sequel.
出处
《中国实用医刊》
2008年第2期30-32,共3页
Chinese Journal of Practical Medicine
