摘要
目的：测定犬ｉｖ紫杉醇后的药动学。方法：犬１０条，随机分为两组，一组先后ｉｖ１．５和３．０ｍｇ·ｋｇ－１两个剂量的紫杉醇，另一组则ｉｖ６．０ｍｇ·ｋｇ－１的紫杉醇，用ＨＰＬＣ测定血药浓度。结果：犬ｉｖ１．５，３．０和６．０ｍｇ·ｋｇ－１３个剂量的紫杉醇后，血浆药时曲线均符合二室模型，ｔ１／２β分别为２．２０，２．０１和２．２４ｈ，ＡＵＣ分别为１．２４，２．７５和６．７２μｇ·ｈ·ｍｌ－１。紫杉醇的主要药动学参数在３个剂量组之间无显著性差异。结论：紫杉醇在犬体内的处置无剂量依赖性。
OBJECTIVE: To determine pharmacokinetics of taxol in dogs. METHOD: Ten dogs were divided into two groups at random, group 1 for iv 1.5 and 3.0 mg·kg -1 of taxol, group 2 for iv 6.0 mg·kg -1 of taxol, and then the plasma concentration of taxol was determined by HPLC. RESULTS: After iv 1.5, 3.0 and 6.0 mg·kg -1 of taxol, the plasma concentration time curves could be fitted to two compartment model, the t 1/2β was 2.20, 2.01 and 2.24 h, and the AUC was 1.24, 2.75 and 6.72 (μg·h)·ml -1 , respectively. There was no significant difference of main pharmacokinetic parameters among three dose group. CONCLUTION: The disposition of taxol in dogs is dose independent.
出处
《中国药学杂志》
CAS
CSCD
北大核心
1997年第10期603-605,共3页
Chinese Pharmaceutical Journal
