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脂肪细胞因子与动脉粥样硬化 被引量：4

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摘要 近年来，随着动脉硬化研究的深入，脂肪组织与动脉硬化的关系显得越来越密切。目前已经明确认识到脂肪组织不仅只是一个能量储存器官，也是一个重要的内分泌器官，能够以旁自分泌和远距分泌方式分泌生物活性因子或因子样分子，被称为脂肪细胞因子（adipocytokine），包括瘦素（1eptin）、抵抗素（resistin）、脂联素、肿瘤坏死因子α（TNF-α）等，它们影响胰岛素敏感性、血压水平、内皮功能、纤溶活动及炎症反应，参与调节机体的重要病理生理过程。脂肪细胞因子不仅可以通过影响传统危险因素促进动脉粥样硬化的发生，还可以作用于血管壁组织，通过影响血管内皮细胞、平滑肌细胞和单核／巨噬细胞,从多环节影响动脉粥样硬化的进程。
作者 毛节明 郭艳红
机构地区 北京大学第三医院心内科
出处 《中国循环杂志》 CSCD 北大核心 2008年第2期81-82,共2页 Chinese Circulation Journal
关键词 脂肪细胞因子 动脉粥样硬化 内分泌器官 肿瘤坏死因子α 单核/巨噬细胞 生物活性因子 胰岛素敏感性 病理生理过程
分类号 R587.1 [医药卫生—内分泌] R543.5 [医药卫生—心血管疾病]
  • 相关文献

参考文献4

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  • 2Jung HS, Park KH, Cho YM, et al. Resistin is secreted from macrophages in atheromas and promotes atherosclerosis. Cardiovasc Res,2006,69:76-85.
  • 3王学英,郭艳红,郭丽君,高炜.血浆脂联素与冠状动脉病变程度的相关性分析[J].北京大学学报（医学版）,2007,39(6):599-602. 被引量：7
  • 4Schnabel R, Messow CM, Lubos E, et al. Association of adiponectin with adverse outcome in coronary artery disease patients : results from the AtheroGene study. Eur Heart J,2008,29:649-657.

二级参考文献11

  • 1刘岩,邹大进,李慧,陈月,丁继军,郑兴,郭鹏飞.低脂联素血症是冠状动脉粥样硬化严重程度的重要标志[J].中华内分泌代谢杂志,2005,21(1):5-8. 被引量：111
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  • 8Arita Y, Kihara S, Ouchi N, et al. Adipocyte-defived plasma protein adiponectin acts as a platelet-derived growth factor-BB binding protein and regulates growth factor - induced common postreceptor signal in vascular smooth muscle cell [ J ]. Circulation, 2002, 105 : 2893 -2898.
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共引文献6

同被引文献50

  • 1程王生,张钲,白锋,黄晏.冠心病患者中血管内皮细胞钙黏蛋白的检测及临床意义[J].中国现代医学杂志,2006,16(6):851-853. 被引量：15
  • 2李筱雯,艾华,张宝慧.肥胖与脂联素[J].心血管康复医学杂志,2006,15(3):303-306. 被引量：3
  • 3HU Wen-lan QIAO Shu-bin HOU Qing YUAN Jian-song.Plasma resistin is increased in patients with unstable angina[J].Chinese Medical Journal,2007(10):871-875. 被引量：14
  • 4Zuk PA,Zhu M,Mizuno H,et al.Multilineage cells from human adipose tissue: implications for cell-based therapiesTissue Engineering,2001.
  • 5Mizuno H,Zuk PA,Zhu M,et al.Myogenic differentiation by human processed lipoaspirate cellsPlastic and Reconstructive Surgery,2002.
  • 6Patricia A. Zuk,Min Zhu,Peter Ashjian,et al.Human adipose tissue is a sourse of multipotent stem cellsMolecular Biology,2002.
  • 7De Ugarte DA,Allonso Z,Zuk PA,et al.Differential expression of stem cell mobilization-associated molecules on multi-lineage cells from adipose tissue and bone marrowImmunology Letters,2003.
  • 8De Ugarte DA,Morizono K,Elbarbary A,et al.Comparison of multi-lineage cells from human adipose tissue and bone marrowCells Tissues Organs,2003.
  • 9Gregoire FM,Smas CM,Sul HS.Understanding adipocyte differentiationPhysiological Reviews,1998.
  • 10Darlington G J,Ross S E,MacDougald O A.The role of C/EBP genes in adipocyte differentiationJournal of Biological Chemistry,1998.

引证文献4

二级引证文献15

中国循环杂志
2008年 第2期

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