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脂联素基因多态性与原发性高血压研究进展 被引量：2

The Relationship Between Adiponectin Gene Polymorphismand and Essential Hypertension
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摘要 脂联素是脂肪细胞特异性细胞因子,与糖、脂代谢、胰岛素抵抗密切相关,具有抗炎、抗动脉粥样硬化特性。脂联素基因序列中存在相当数量的等位基因单核苷酸多态性(SNPs),+45T/G、+164I/T和+276G/TSNPs发生频率在原发性高血压(EH)中增高,直接影响脂联素血浆浓度。脂联素基因SNPs是EH的一个新易感因素。 Adiponectin, an adipocyte--secreted protein, is known to have glycometablolism, lipid metabolism, insulin resistance anti--atherogenic, anti--inflammatory and diabetic properties. Adiponectin gene （APM1） have more than 10 single nucleotide polymorphisms. ＋45T/G, ＋ 164I/T and ＋276G/T SNPs have been frequently referred to be in association with EH and plsama adiponectin concentration. Mutation in APM 1 gene was susceptibility of gene for EH.
作者 唐晓明 李洁琪
机构地区 核工业成都 贵阳医学院附属医院心内科
出处 《医学与哲学（B）》 2008年第5期58-59,77,共3页 Medicine & Philosophy(B)
关键词 脂联素 基因多态性 原发性高血压 adiponectin,gene polymorphism,essential hypertension
分类号 R544.1 [医药卫生—心血管疾病]
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医学与哲学（B）
2008年 第5期

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