摘要
目的:研究乙肝表面抗原(HBsAg)阳性的孕妇实行HBIG被动免疫阻断后血中HBV-DNA水平与母婴宫内感染HBV的关系,探讨孕妇HBV-DNA载量与宫内感染HBV的相关性。方法:对在产前建卡检查的孕妇中筛查出HBsAg阳性孕妇124例,按自愿的原则,根据是否进行产前HBIG阻断而分组,采用荧光定量PCR方法,检测两组在孕28周时和分娩时血清中HBV-DNA水平及其婴儿脐带血中HBV-DNA水平。结果:随着孕妇血中HBV-DNA水平的增高,胎儿发生宫内感染率有增高的趋势,产前HBIG被动免疫阻断组与对照组的宫内感染率比较差异显著,有统计学意义(χ2=7.34,P<0.01)。结论:孕妇血中HBV-DNA水平与是否发生母婴宫内感染HBV密切相关,孕期产前定期注射HBIG可以有效的降低宫内感染率。
Objective： The relativity both HBV - DNA loads in pregnant and HBV mother - to - child transmission was studied when the HBeAg positive pregnant women were treated with HBIG immuno - blocking therapy. Methods： 124 pregnant women diagnosed as HBeAg positive patients according to their card - building were divided into groups if they were treated with objective immuno - blocking therapy of one＇s own will. The levels of HBV - DNA in the rabbits and umbilicalblood serum were detected by real -time quantification PCR in pregnant women at 28 weeks and delivery time, respectively, Results：With the increase of HBV - DNA loads in the blood of pregnant women, the ratio of intrauterine infection was increased. Compared to the control, the pregnant women treated with HBIG immuno -blocking therapy have the remarkable difference （2 = 7. 34, P 〈 0, 01 ）. Conclusion： There was relationship between HBV - DNA loads in the blood of pregnant women and HBV intrauterine infection. The ratio of intrauterine infection could be effectively decreased after the pregnant was injected regularly.
出处
《中国卫生检验杂志》
CAS
2008年第3期481-482,共2页
Chinese Journal of Health Laboratory Technology
基金
秦皇岛市科学技术研究与发展指导计划项目(2006-67)
