摘要
目的:研究鲜驴奶对小鼠免疫功能的影响;及鲜驴奶体外抑制结核杆菌生长作用。方法:应用环磷酰胺制备免疫低下小鼠模型,以不同剂量鲜驴奶作为受试物灌胃20d,研究鲜驴奶对小鼠脾脏及胸腺指数、抗体分泌细胞功能、血清溶血素水平、脾脏淋巴细胞转化功能等免疫指标的影响;按照《结核病诊断细菌学检验规程》以覆盖法研究鲜驴奶体外抑制结核杆菌生长作用。结果:鲜驴奶高剂量组可以增加血清溶血素含量并可提高小鼠脾细胞抗体分泌细胞功能;大剂量(0.4、0.5ml)驴奶脂肪抑菌效果明显。结论:鲜驴奶对免疫力低下小鼠的免疫功能具有一定的增强作用;鲜驴奶脂肪在体外具有抑制结核杆菌生长的作用。
Objective： To study the effect of fresh donkey＇s milk on the immune function of mice, and to study the effect of fresh donkey＇s milk on inhibitting the growth of Mycobacterium tuberculosis. Methods： The immunosuppressed mice induced by cyclophosphamide were administrated with fresh donkey＇s milk for 20 days.The indexes of thymus and spleen, the ability of antibody secreting cell, the levels of serum hemolysin and the ability of lymphocyte transformation were measured. According to The Laboratory Science Procedure of Diagnostic Bacteriology in Tuberculosis, we study the effect of fresh donkey＇s milk on inhibitting the growth of Mycobacterium tuberculosis. Results： The high dose groups of fresh donkey＇s milk can enhance the ability of antibody secreting cell and the levels of serum hemolysin. The fat of fresh donkey＇s milk （0.4ml, 0.5ml） can inhibit the growth of Mycobacterium tuberculosis. Conclusions： The fresh donkey＇s milk can enhance the immune function of mice. The fresh donkey＇s milk can inhibit the growth of Mycobacterium tuberculosis in vitro.
出处
《食品科学》
EI
CAS
CSCD
北大核心
2008年第5期423-426,共4页
Food Science
关键词
鲜驴奶
小鼠
免疫功能
结核杆菌
fresh donkey＇s milk
mice
immune function
Mycobacterium tuberculosis
