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Caveolin-1和E-cadherin在肾细胞癌中的表达及其意义 被引量:6

Expression of Caveolin-1 and E-cadherin in renal cell carcinoma
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摘要 目的:探讨Caveolin-1、E-cadherin在肾细胞癌中的表达及其临床意义。方法:采用免疫组织化学EnVision法检测41例肾细胞癌切除标本中Caveolin-1和E-cadherin的表达,并分析表达情况与肿瘤的生物学行为的关系。结果:Caveolin-1在肾细胞癌中的表达阳性率为41.5%,与肿瘤分期、Fuhrman分级及患者年龄呈正相关(P<0.05);E-cadherin表达阳性率为24.4%,低于癌旁肾组织(50%),E-cadherin表达与肿瘤细胞核分级相关(P<0.05),与其他临床病理参数之间无相关性。Caveolin-1和E-cadherin两者之间表达无相关性。结论:Caveolin-1过表达及E-cadherin的异常表达,可能在肾细胞癌的生长、分化中发挥重要作用。 Objective:To evaluate expression of Caveolin-1 and E-cadherin in renal cell carcinoma and to investigate their associations with clinicopathological parameters. Methods: Expression of Caveolin-1 and E-cadherin were evaluated by immunohistochemistry in 41paraffin embedded renal cell carcinoma specimens. Associations between their expressions and pathological stage, tumor grade, size of tumor were analyzed. Results: Of 41 tumors 17 (41.5 % ) were considered Caveolin-1 positive. Significant associations between Caveolin-1 expression and pathological stage, tumor grade,and age of patient were also found(P〈0.05). Positive rate of E-cadherin expression in 41 tumors is 24.4%, which was lower than in nomal tissues. Associations between E-cadherin expression and tumor grade was found(P〈0.05). There were no significant associations between E-cadherin expression and other clinicopathological parameters, Conclusions: Caveolin-1 over expression and abnomal expression of E-cadherin might have an important role in growth and differentiation of renal cell carcinoma.
出处 《临床泌尿外科杂志》 2008年第4期286-288,共3页 Journal of Clinical Urology
关键词 肾肿瘤 细胞癌 微囊蛋白 肿瘤标志物 Renal tumor Cell carcinoma Caveolin Tumor marker
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参考文献12

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二级参考文献10

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