摘要
目的:制备非诺贝特缓释微丸。方法:采用BZJ-360M离心包衣造粒机制备微晶纤维素空白丸核和非诺贝特含药素丸,并在此基础上进行丙烯酸树脂水分散体(Eudragit NE 30D)包衣。用释放度测定法考察影响药物释放的各种因素,对包衣微丸体外释药机制进行研究。结果:包衣材料为Eudragit NE 30D,增重3%时包衣微丸呈现良好的缓释效果,体外释药过程基本符合Higuchi方程:Q=0.436+30.316t1/2(r=0.9997)。结论:成功的制备了非诺贝特缓释微丸。
OBJECTIVE To prepare fenofibrate sustained-release pellets. METHODS Fenofibrate pellets were prepared by means of powder layering with the centrifugal granulation equipment, fenofibrate pellets were coated in the same equipment whh Eudragit NE 30D as coating material. The release mechanism of the drug from the pellets was studied. RESULTS The main factors affecting the release rate were the type and the amount of the coating material applied, Release of the drug from pellets was in accordance with Higuchi equation：Q= 0. 436 ＋ 30. 316 t^1/2 （r = 0, 999 7）. CONCLUSION The method and the formula tion are successful in providing slow and steady release of fenofibrate from sustained-release pellets.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2008年第9期712-715,共4页
Chinese Journal of Hospital Pharmacy
