期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

增生性瘢痕和瘢痕疙瘩的局部治疗进展 被引量：8

下载PDF
导出
摘要 瘢痕是创伤修复过程中的一种必然产物。是由真皮组织过度增生形成的。增生性瘢痕局限于病损区域内，而瘢痕疙瘩常超过原损伤界限。增生性瘢痕和瘢痕疙瘩属于病理性瘢痕，可以出现瘙痒、疼痛等不适症状，影响容貌，甚至发生瘢痕挛缩导致严重的功能障碍。迄今为止。病理性瘢痕的发病机制还不明确，因此治疗困难。手术治疗联合加压治疗、放射治疗及皮损内注射糖皮质激素等是首选的治疗方法。局部疗法是局部的非侵入性治疗。因其方便、无创、痛苦小也在临床上广泛应用，并常与手术治疗或注射治疗联合使用。本文仅就增生性瘢痕和瘢痕疙瘩的局部治疗进展作一综述。
作者 丛林 常冬青 苏有明 杨蓉娅
机构地区 北京军区总医院全军皮肤性病诊疗中心
出处 《实用医学杂志》 CAS 2008年第9期1469-1471,共3页 The Journal of Practical Medicine
关键词 增生性瘢痕 瘢痕疙瘩 局部治疗 病理性瘢痕 非侵入性治疗 手术治疗 糖皮质激素 皮损内注射
分类号 R622 [医药卫生—整形外科]
  • 相关文献

参考文献34

  • 1Costa A M, Peyrol S, Porto L C, et al. Mechanical forces induce scar remodeling : study in non-pressure-treated versus pressure-treated hypertrophic scars[J]. Am J Pathol, 1999,155 (5) : 1671-1679.
  • 2Macintyre L, Baird M. Pressure garments for use in the treatment of hypertrophic scars-an evaluation of current construction techniques in NHS hospitals [J]. Burns, 2005,31 ( 1 ) : 11-14.
  • 3Cheng W, Saing H, Zhou H, et al. Ultrasound assessment of scald scars in Asian children receiving pressure garment therapy [ J ]. J Pediatr Surg, 2001,36 (3) : 466-469.
  • 4Van den Kerckhove E, Stappaerts K, Fieuws S, et al. The assessment of erythema and thickness on burn related scars during pressure garment therapy as a preventive measure for hypertrophic scarring [J]. Burns, 2005,31 (6) : 696-702.
  • 5Gold M, Foster T D, Adair M A, et al. Prevention of hypertrophic scars and keloids by the prophylactic use of topical silicone gel sheets following a surgical procedure in an office setting [J]. Dermatol Surg, 2001,27(7) :641-644.
  • 6de Oliseira G V, Nunes T A, Magna L A, et al. Silicone versus nonsilicone gel dressings:a controlled trial [J]. Dermatol Surg, 2001,27(8) :721-726.
  • 7Signorini M, Clementoni M T. Clinical evaluation of a new selfdrying silicone gel in the treatment of scars: a preliminary report [J]. Aesthetic Plast Surg, 2007,31(2) : 183-187.
  • 8Chan K Y, Lau C L, Adeeb S M, et al. A randomized, placebo-controlled, double-blind, prospective clinical trial of silicone gel in prevention of hypertrophic scar development in median stemotomy wound [J]. Plast Reconstr Surg, 2005,116 (4) : 1013-1020.
  • 9Berman B, Flores F. Comparison of a silicone gel-filled cushion and silicon gel sheeting for the treatment of hypertrophic or keloid scars [J]. Dermatol Surg, 1999,25(6) :484-486.
  • 10Hanasono M M, Lum J, Carroll L A, et al. The effect of silicone gel on basic fibroblast growth factor levels in fibroblast cell culture [J]. Arch Facial Plast Surg, 2004,6(2):88-93.

二级参考文献17

  • 1陈晓栋,王强,张国成,叶顺章.血小板衍化生长因子受体蛋白在瘢痕疙瘩中的表达[J].中华皮肤科杂志,2003,36(12):687-689. 被引量：6
  • 2陈晓栋,顾黎雄,赵洪瑜,刘安齐,曹双林.手术切除、糖皮质激素注射联合术后放疗治疗瘢痕疙瘩的疗效观察[J].中华皮肤科杂志,2006,39(1):52-53. 被引量：36
  • 3骆丹,缪旭,吉玺,吴迪,朱洁,林向飞,徐丽贤.咪喹莫特对朗格汉斯细胞及角质形成细胞细胞因子mRNA表达及分泌水平的影响[J].中华微生物学和免疫学杂志,2006,26(3):274-278. 被引量：3
  • 4Chang YC,Madkan V,Cook-Norris R,et al.Current and potential uses of imiquimod.South Med J,2005,98:914-920.
  • 5Berman B,Villa A.Imiquimod 5% cream for keloid management.Dermatol Surg,2003,29:1050-1051.
  • 6Meyer LJ,Russell SB,Russell JD,et al.Reduced hyaluronan in keloid tissue and cultured keloid fibroblasts.J Invest Dermatol,2000,114:953-959.
  • 7Jacob SE,Berman B,Nassiri M,et al.Topical application of imiquimod 5% cream to keloids alters expression genes associated with apoptosis.Br J Dermatol,2003,149 Suppl 66:62-65.
  • 8Al-Attar A,Mess S,Thomassen JM,et al.Keloid pathogenesis and treatment[J].Plast Reconstr Surg,2006,117(1):286-300.
  • 9Coors EA,Schuler G,Von Den Driesch P.Topical imiquimod as treatment for different kinds of cutaneous lymphoma[J].Eur J Dermatol,2006,16(4):391-393.
  • 10Imbertson LM,Beaurline JM,Couture AM,et al.Cytokine induction in hairless mouse and rat skin after topical application of the immune response modifiers imiquimod and S-28463[J].J Invest Dermatol,1998,110(5):734-739.

共引文献19

同被引文献144

引证文献8

二级引证文献69

实用医学杂志
2008年 第9期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部