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不同年龄妇女的胚胎着床和临床妊娠结局分析 被引量:3

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摘要 目的:探讨体外受精-胚胎移植(IVF-ET)周期中不同年龄妇女的临床妊娠结局。方法:回顾性分析2002年1月至2006年12月在南方医院生殖医学中心进行IVF-ET治疗的1829个新鲜周期,比较不同年龄组之间的胚胎着床率、临床妊娠率、自然流产率。结果:本研究的平均临床妊娠率为46.7%。≤34岁组、35~37岁组、38~40岁组、41~42岁组、≥43岁组的胚胎着床率分别为33.3%、25.2%、13.3%、13.8%、5.0%,差异有显著性(P=0.000);临床妊娠率分别为50.5%、45.4%、25.8%、27.5%、11.1%,差异有显著性(P=0.000);自然流产率分别为5.3%、10.8%、11.8%、15.8%、0%,差异有显著性(P=0.004)。结论:患者年龄是影响IVF-ET妊娠结局的重要因素。随年龄增加,尤其是38岁以上的妇女,胚胎着床率与临床妊娠率明显降低,自然流产率显著升高。
出处 《实用医学杂志》 CAS 2008年第9期1539-1541,共3页 The Journal of Practical Medicine
基金 973课题基金资助项目(编号:2007CB948104) 国家自然科学基金资助项目(编号:30470657) 广东省自然科学基金资助项目(编号:04020416)
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  • 1孙海翔,胡娅莉,王玢,陈骞,张宁媛,陈华,王俊霞.体外受精移植胚胎数对临床妊娠率的影响[J].中国实用妇科与产科杂志,2005,21(12):730-732. 被引量:8
  • 2[1]Faddy MJ,Gosden RG,Gougen A,et al.Accelerated disappearance of ovarian follicles in mid-life:implication for forecasting menophause.Hum Reprod,1992,7:1342-1346.
  • 3[2]Bancsi LJMM,Broekmans FJM,Eijkemans MJC,et al.Predictors of poor ovarian responses in in vitro fertilization:a prospective study comparing basal markers of ovarian reserve.Fertil Steril,2002,77:328-336.
  • 4[3]Akande VA,Fleming CF,Hunt LP,et al.Biological versus chronological ageing of oocytes,distinguishable by raised FSH levels in relation to the success of IVF treatment.Hum Reprod,2002,17:2003-2008.
  • 5[4]Keay SD,Lunenfeld B,Eshel A,et al.Assisted conception following poor ovarian responses to gonadotrophin stimulation.Br J Obstet Gynaecol,1997,14:521-527.
  • 6[5]Faber BM,Mayer J,Cox B,et al.Cessation of gonadotropin-releasing hormone agonist therapy combined with high-dose gonadotropin stimulation yields favorable pregnancy results in low responders.Fertil Steril,1998,69:826-830.
  • 7[6]Surrey ES,Bower J,Hill DM,et al.Clinical and endocrine effects of a microdose GnRH agonist flare regimen administered to poor responders who are undergoing in vitro fertilization.Fertil Steril,1998,69:419-424.
  • 8[7]Lindheim SR,Barad DH,Witt B,et al.Short-term gonadotropin suppression with oral contraceptives benefits poor responders prior to controlled ovarian hyperstimulation.J Assist Reprod Genet,1996,13:745-747.
  • 9[8]Kailasam C,Keay SD,Wilson P,et al.Defining poor ovarian response during IVF cycles,in women aged <40 years,and its relationships with treatment outcome.Hum Reprod,2004,19:1544-1547.
  • 10[9]Schachter M,Friedler S,Raziel A,et al.Improvement of IVF outcome in poor responders by discontinuation of GnRH analogue during the gonadotropin stimulation phase--a function of improved embryo quality.J Assist Reprod Genet,2001,18:197-204.

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  • 1Sneed ML,Uhler ML,Grotjan HE,et al.Body mass index:impact on IVF success appears age-related.Hum Reprod,2008,23(8):1835-1839.
  • 2Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group.Revised 2003 consensus on diagnostic criteria and longterm health risks related to polycystic ovary syndrome.Fertil Steril,2004,81 (1):19-25.
  • 3Keay SD,Liversedge NH,Mathur RS,et al.Assisted conception following ovarian response to gonadotrophin.Br Obster Gynaecol,1997,104(5):521-527.
  • 4Meyer WR,Lunenfeld B,Eshel A,et al.Evidence of gonadal and gonadotropphin antibodies in women with a suboptimal and gonadoetophin antibodies in women with a suboptimd ovarian response to exogenous gonadotrophin.Fertil Steril,1990,75 (5):795-799.
  • 5Yue J.Obstetrics and gynecology.6th eds.Beijing:People's Health Publishing House,2004:358.(in Chinese)乐杰.妇产科学.6版.北京:人民卫生出版社,2004:358.
  • 6Lashen H,Ledger W,Bemal AL.Extremes of body mass do not adversely affect the outcome of superovulation and in-vitro fertilization.Hum Reprod,1999,14(3):712-715.
  • 7Dokras A,Baredziak L,Blaine J.Obstetric outcomes after in vitro fertilization in obese and morbidly obese women.Obstet Gynecol,2006,108(1):61-69.
  • 8Spandorfer SD,Kump L,Goldschlag D.Obesity and in vitro fertilization:negative influences on outcome.J Reprod Med,2004,49 (12):973 -977.
  • 9Thum MY,El-Sheikhah A,Faris R.The influence of body mass index to in-vitro fertilization treatment outcome,risk of miscarriage and pregnancy outcome.J Obstet Gynaecol,2007,27(7):699-702.
  • 10Dechaud H,Anahory T,Reyftmann L.Obesity does not adversely affect results in patients who are undergoing in vitro fertilization and embryo transfer.Eur J Obstet Gynecol Reprod Biol,2006,127(1):88-93.

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