摘要
目的探讨多学科技术联合125Ⅰ治疗恶性梗阻性黄疸的疗效及不良反应。方法18例癌性梗阻性黄疸,A组9例,采用经食管逆行胆管引流(ERBD)术后CT引导下植入125Ⅰ粒子,B组9例,术中植入125Ⅰ后行胆肠吻合术,2个月后观察经两个方案治疗后缓解率并复查肝功能。结果A组肿瘤缓解率为44%,B组肿瘤缓解率为56%,两组肿瘤缓解率差异无统计学意义(P>0.05),肝功能恢复也无明显差异(P>0.05)。结论多学科技术联合125Ⅰ治疗癌梗阻性黄疸有较好疗效,术中与CT引导下植入对于肿瘤缓解率、肝功能恢复无明显差异,CT引导下植入患者术后恢复较快。
Objective To explore the effectiveness and safety of the combined multi-disciplinary techniques with ^125I seeds to treat the malignant obstructive jaundice. Methods 18 cases of malignant obstructive jaundice were divided into 2 groups. A group with ERBD technique followed by CT-guided interstitial ^125 I seeds implantation, B group with ^125 I seeds implantation during the operation and gallbladder-intestine anastomosis later on. After 2 months amelioration （CR,PR,SD,PD）of the obstructive jaundice was observed with inspection of liver functions. Results All cases were ameliorated with 44% patients in group A and 56% patients in group B, showing no significant statistical difference （P 〉 0.05） ; and the liver functions were also relieved in both groups with no statistical significance （P 〉 0.05）. Conclusion Multi-disciplinary techniques combined with ^125 I seeds implantation is effective in the management of the malignant obstructive jaundice. No significant difference for relief and liver function were found between CT- guided and during operation interstitial ^125 I seeds implantations, but it seems more quickly relief or recovery was achieved in the latter.
出处
《介入放射学杂志》
CSCD
2008年第5期346-348,共3页
Journal of Interventional Radiology
关键词
恶性梗阻性黄疸
胰腺癌
肝功能
^125I粒子
术中植入
Malignant obstructive jaundice
Pancreatic carcinoma
Liver function
^125 I seed
Implantation during operation
