摘要
目的评价大剂量静脉用丙种球蛋白(IVIG)治疗极低出生体重儿呼吸机相关性肺炎(VAP)效果。方法将60例确诊为呼吸机相关性肺炎极低出生体重儿按随机抽样原则分为对照组(30例)、治疗组(30例)。两组患儿综合治疗和护理措施相同,均选择同类广谱敏感抗生素,细菌培养阳性者,根据药物敏感性选择抗生素药物。治疗组加用静脉用丙种球蛋白,每次500mg/kg,静脉滴注,每天1次,连续用3 d。结果治疗后两组病死率比较有显著性意义(P<0.05),5d内顺利撤机两组比较有显著性意义(P<0.05),7d后复查胸片炎症吸收好转两组比较有显著性意义(P<0.05)。结论应用丙种球蛋白治疗婴儿呼吸机相关性肺炎疗效确切。
Objectives To estimate the effect of large dose immunoglobulin in treatment of very low birth weight infant with ventilator- associated pneumonia, Methods Sixty very low birth weight infants were randomly divided into blank control group （n= 30） and treated group （n = 30）, The infants of treated group were IV administered drip with 500 mg/kg of immunoglobulin once daily for 3 days in addition to the conventional antibiotic and supportive therapy, Results The mortality, the ratios of successful withdrawing breathing machine, and the resorption of inflammatory infiltration demonstrated by plain chest film all showed significant difference between these two groups （P〈0.05）, Conclusions Large dose immunoglobulin is effective in treatment of ventilator- associated pneumonia of very low birth weight infant.
出处
《实用预防医学》
CAS
2008年第2期485-486,共2页
Practical Preventive Medicine
关键词
丙种球蛋白
呼吸机相关性肺炎
婴儿
新生
Immunoglobulin
Ventilator- associated pneumonia
Infant
Neonate
