摘要
目的了解住院患者临床分离菌的分布及耐药情况,为指导临床合理用药提供参考依据。方法采用Vitek-2全自动微生物分析仪及纸片扩散法(Kirby-Bauer),对778株临床分离菌进行鉴定及药物敏感试验。结果778株分离菌中革兰阴性(G-)杆菌占52.70%,革兰阳性(G+)球菌占35.60%,真菌占11.70%。G+球菌对万古霉素的敏感率均达100%,而G-杆菌对碳青霉烯类抗生素的敏感率未达100%,其中铜绿假单胞菌对亚胺培南和美洛培南的耐药率分别为24.00%和18.67%,鲍曼不动杆菌对亚胺培南和美洛培南的耐药率均为4.76%。结论该资料对医院临床抗感染治疗及抗菌药物的选择有参考价值。
Objective To analyze the isolated bacterial distribution and antibiotic resistance of the inpatients in order to give advise for the clinical applications of antibiotics. Methods The bacterial identification and susceptibility test were performed by automatic bioanalysis- Vitek-2 and Kirby- Bauer methods. Results Of 778 clinical isolates selected randomly,Gram negative organisms accounted for 52.70%, Gram positive organisms accounted for 35.60% ,and eumycetes accounted for 11.70%. Vancomycin was the most potent antibiotic against Gram positive organisms,the susceptible rate of Gram positive organisms against vancomycin was 100%. Not all the susceptivity rate of Gram negative bacilli against carbapenem antibiotics was 100%. The resistant rate of Pseudomonas aeruginosa against imipenem was 24.00%,and the resistant rate of Pseudomonas aeruginosa aginst meropenem was 18.67%. The resistant of Acinetobacter baumannii against imipenem was 4.76%,and the resistant of Acinetobacter baumannii against meropenem was 4. 76%. Conclusion The results can be used as the guidance for appropriately choosing antibiotics in order to improve the treatment of infection caused by pathogenic bacteria.
出处
《中国药业》
CAS
2008年第11期61-63,共3页
China Pharmaceuticals
关键词
革兰阳性球菌
革兰阴性杆菌
细菌
抗药性
抗生素
Gram positive organisms
Gram negative bacilli
bacteria
antibiotic resistance
antibiotic