摘要
目的探讨产前应用不同疗程地塞米松对于早产孕妇母儿预后的影响。方法回顾性分析85例28-34周早产母儿临床资料。结果在≤34周早产孕妇产前应用地塞米松可以显著降低新生儿呼吸窘迫综合征(NRDS)的发生率(P<0.05),多疗程与单疗程治疗组之间无明显差异(P>0.05);地塞米松未增加新生儿缺血缺氧性脑病,新生儿感染及新生儿死亡率,对孕妇产褥感染也无明显的影响(P>0.05);伴胎膜早破应用多疗程地塞米松组产褥感染率明显增加,高于对照组及单疗程治疗组(P<0.05)。结论在≤34周早产孕妇应用地塞米松可预防NRDS发生,多疗程应用未增加对NRDS保护作用,对胎膜早破者增加产褥感染机率。
Objective： To assess the safety and effectiveness of prenatal multiple and single course glueocorticoids treatment on preterm birth infants. Methods ： We retrospectively analyzed 85 cases of preterm matemal and neonatal clinical data. Results ： Dexamethasone treatment before labor may lower the incidence of neonatal respiratory distress syndrome （NRDS） of preterm babies bem at ≤34 weeks＇gestation （ P 〈0. 05）, the effects of multiple courses and single course of dexamethasone were similar （ P 〉 0. 05）. And it could not increase the morbidity and mortality of hypoxic - ischemic encephalopathy （ HIE）, neonatal septicemia and puerperal infection （ P 〉 0. 05）, But multiple courses of dexamethasone treatment may increase the puerperal infection ratio on the pregnant women at ≤34 weeks＇gestation with preterm premature rupture of the membranes, （PPROM）, higher than the control and single course treatment. Conclusions ： Exposure to multiple or a single course of antenatal corticosteroids resulted in a significant reduction in the incidence of NRDS in preterm infants bern at 〈34 weeks＇gestation, But it was associated with an increased incidence of maternal puerperal infection in PPROM mothers.
出处
《中国优生与遗传杂志》
2008年第6期74-75,76,共3页
Chinese Journal of Birth Health & Heredity
关键词
早产
地塞米松
剂量
胎膜早破
预后
Dexamethasone
Infant
Premature
Respiratory distress syndrome
multiple course
