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Caveolin-1在血管生成中的作用 被引量：3

Role of caveolin-1 in angiogenesis
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摘要 Caveolin-1是细胞膜表面内陷结构Caveolae的标志性蛋白,识别并与多种信号蛋白分子相作用,在内皮细胞内表达量较高,在血管内皮细胞增殖、迁移和分化过程中具有重要作用,在小鼠动物模型中对血管生成、肿瘤生长起抑制作用,有可能成为抑制肿瘤血管生成的靶蛋白。 Caveolin -1 is the marker protein of caveolae, expresses abundantly in endothelial cells , recognizes and interacts with many signal protein kinases, and thus play an important role in endothelial cells proliferation, migration and differentiation in vitro. The caveolin - 1 transgenic and knockout mouse investigations showed that caveolin - 1 inhibits angiogenesis and may be a target for angiogenesis.
作者 房凯 姜懿凌 赵雨杰
机构地区 中国医科大学基础医学院生物信息学教研室 中国医科大学
出处 《现代肿瘤医学》 CAS 2008年第6期1053-1054,共2页 Journal of Modern Oncology
关键词 CAVEOLIN-1 血管生成 内皮细胞 肿瘤 caveolin - 1 angiogenesis endothelial cell tumor
分类号 R730.3 [医药卫生—肿瘤]
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参考文献15

  • 1Babak Razani, Scott E, M Lisanti. Caveolae: from cell biology to animal biology [ J ]. Pharmacol Rev, 2002, 54:431 - 467.
  • 2Jenkins RB, Qian J, Lee HK, et al. A molecular cytogenetic analysis of 7q31.1 in prostate cancer[J]. Cancer Res, 1998,58:759 -766.
  • 3Okamoto T, Schlegel A, Scherer PE, et al. Caveolins,a family of scaffolding proteins for organizing "preasscmbled signaling complexes" at the plasma membrane[ J ]. J Biol Chem, 1998 ,273 ( 10 ) : 5419 - 5422.
  • 4Lisanti MP, Scherer PE, Vidugiriene J, et al. Characterization of caveolin-rich membrane domains isolated from an endothelial - rich source : implications for human diease[J]. J Cell Biol, 1994, 126:111 -126.
  • 5Kai Fang, Wei Fu, Andrew Beardsley, et al. Caveolin - 1 inhibits endothelial cell proliferation by arrest the cell cycle at G0/G1 phase[J]. Cell Cycle,2007,6(2) :199 -204.
  • 6Cohen AW, Park DS,Woodman SE,et al. Caveolin -1 null mice develop cardiac hyperthropy with hyperaetivation of p42/44MAP kinase in cardiac fibroblasts[J]. Am J Pathol Cell Physiol,2003, 284 : C457 - C474.
  • 7Engelman JA, Wykoff CC, Yasuhara S, et al. Recombinant expression of caveolin - 1 in oncogenically transformed cells abrogates anchorage - independent growth [ J ]. J Biol Chem, 1997,272 : 16374 - 16381.
  • 8Merk Drab, Paul Verkade, Marlies Elger, et al. Loss of caveolae, vascular dysfunction, and pulmonary defects in caveolin - 1 gene - disrupted mice[ J ]. Scinece,2001,293 (5539) :2449 - 2452.
  • 9Marie - Odile Part, Bela Anand - Apte, Paul L Fox. Differential caveolin - 1 polarization in endothelial cells during migration in two and three dimensions[J]. Mol Biol of the Cell, 2003,14:3156 - 3168.
  • 10Andrew Beardsley, Kai Fang, Heather Mertz, et al. Loss of caveolin- 1 polarity impedes endothelial cell polarization and directional movement [ J ]. J Biol Chem,2005, 280 (5) :3541 - 3547.

同被引文献44

  • 1王振涛,韩丽华,朱明军,张淑娟,曹生海.丹参注射液促心肌梗塞后大鼠缺血心肌血管新生作用及对相关生长因子的影响研究[J].时珍国医国药,2007,18(6):1315-1318. 被引量：11
  • 2陈灏珠．实用内科学[M]．北京：人民卫生出版社，2006：1834，1918．
  • 3Lee MY, Ryu JM, Lee SH, et al. Lipid rafts play an important role for maintenance of embryonic stem cell self-renewal [ J ]. J Lipid Res, 2010,51 (8) :2082 -2089.
  • 4Luo DX, Cao DL, Xiong Y, et al. Novel model of cholesterol efflux from lipid-loadod cells [ J ]. Acta Pharmacol Sin, 2010,31 ( 10 ) : 1243 - 1257.
  • 5Simionescu M, Gafencu A, Antohe F. Transcytosis of plasma macro- molecules in endothelial cells: a cell biological survey[ J]. Microsc Res Tech, 2002, 57(5): 269-288.
  • 6Hillen F, Griffioen AW. Tumour vascularization : sprouting angiogen- esis and beyond[ J], Cancer Metastasis Rev,2007,26 ( 3 - 4 ) : 489 - 502.
  • 7Toomey DP, Murphy JF, Conlon KC. COX-2, VEGF and tumour an- giogenesis [ J]. Surgeon ,2009,7 (3) : 174 - 180.
  • 8Folkmml J. Angiogenesis[ J]. Annu Rev Med,2006,57 : 1 - 18.
  • 9Karamysheva AF. Mechanisms of angiogenesis [ J ]. Biochemistry (Mosc) ,2008,73 (7) : 751 - 762.
  • 10Dickinson PJ, Sterges BK, Higgins R J, et al. Vascular endothelial growth factor mRNA expression and peritumoral edema in canine primary central nervous system tumors [ J ]. Vet Pathol, 2008,45 (2) :131 -139.

引证文献3

二级引证文献11

现代肿瘤医学
2008年 第6期

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