摘要
目的探讨调肝运脾方对腹泻型肠易激综合征(IBS)患者脑内兴奋区域MR信号变化幅度的影响。方法采用自身配对对照方法,运用功能磁共振成像(fMRI)技术,分别观察18例腹泻型IBS患者采用调肝运脾方治疗前后及对照用药后在不同容量直肠气囊刺激下脑内扣带回前皮层(ACC)、脑岛皮层(IC)、前额叶皮层(PFC)和丘脑(THAL)兴奋区域MR信号变化幅度。结果注气量为90 mL时,治疗后IC兴奋区域MR信号变化幅度较治疗前显著降低(P<0.05)。注气量为120 mL时,IC、PFC和THAL兴奋区域MR信号变化幅度均较治疗前显著降低(P<0.05);IC兴奋区域MR信号变化幅度较对照后也呈显著降低(P<0.05)。结论调肝运脾方对IBS患者脑肠轴及其调节机制功能紊乱的干预,与其抑制IBS患者脑内IC、PFC和THAL兴奋区域激活程度有关。
Objective To investigate the Tiaogan Yunpi Decoction on the region of interest regional encephalic activation MR signal intensity variation among diarrhea type irritable bowel syndrome （IBS） patients. Method Adopting self-paired collated method, functional tMRI was used to observe the regional interest MR signal variation of anterior cingulate cortex （ACC）, island cortex （IC）, prefrontal cortex （PFC）, hypothalamus （THAL） before and after the treatment, as well as after the controlled treatment using placebo among 18 diarrhea dominant IBS patients when they were rectum stimulated. Results After the treatment, when the injected gas reached 90 mL, the change of MR signal variation of IC was signifycanfly decreased compared with that before the treatment （P〈0.05）. When the injected gas reached 120 mL, the change of MR signal variation of IC, PFC and THAL were significantly decreased compared with those before the treatment （P〈0.05）. And after the treatment, the change of MR signal variation of IC was significantly decreased compared with the control （P〈0.05）. Conclusion The interference of Tiaogan Yunpi Decoction on the real-regulation of brain-gut axis is related to its inhibiting effect on the activation of IC, PFC and THAI.
出处
《中国中医药信息杂志》
CAS
CSCD
2008年第6期18-20,共3页
Chinese Journal of Information on Traditional Chinese Medicine
基金
上海市卫生局课题(2004L015C)
