摘要
目的:比较罗库溴铵和琥珀胆碱的药效动力学以及用于气管内插管的效果。方法;成年全麻手术患者60例随机分为四组。分别给予2或3倍ED_(95)罗库溴铵(Ⅰ组和Ⅱ组)和2或3倍ED_(95)琥珀胆碱(Ⅱ组和Ⅳ组),记录拇收肌诱发颤搐反应的抑制和恢复过程,分析各组插管效果。结果:Ⅱ组插管评级均为优·Ⅲ组仅占20％。注药后T_1达到最大抑制程度四组基本相同,作用显效时间和T_1达到最大抑制时间,Ⅱ、Ⅲ和Ⅳ组组间比较无明显差异,比Ⅰ组明显短。T_1显现及恢复到25％和95％的时间。Ⅱ组和Ⅳ组都分别比Ⅰ组和Ⅲ组明显长。结论:3倍ED_(95)罗库溴铵的作用起效时间和2或3倍ED_(95)琥珀胆碱相似,插管效果最佳,但临床作用时间明显延长。
Objective: To study clinical pharmacodynamics and efficacy for endotracheal intubation of rocuronium and succinylcholine at different dosage. Method: Sixty adult patients under general anesthesia according to the different drugs and dosage, were randomly divided into four groups. In groupⅠorⅡ,2 or 3×ED_(95) rocuronium were administrated,and in group Ⅲ and Ⅳ, 2 or 3×ED_(95) succinylcholine were given respectively. The course of depression and recovery of twitch response of the adductor pollicis muscle were recorded, and intubating condition were assessed. Result:The intubation condition was excellent in all patients of group Ⅱ,but only in 20％ of group Ⅲ.The degree of twitch at maximal depression was similar between all groups. The lag time and the time of twitch reaching maximal depression were not significantly different between group Ⅱ,Ⅲ and Ⅳ, which were shorter than those of groupⅠ.The times of twitch recovery to 25％ and 95％ of baseline in groupⅠor Ⅳ were significantly longer than in groupⅠor Ⅲ, respectively. Conclusion: 3×ED_(95) rocuronium has similar onset time to 2 or 3×ED_(95) succinylcholine with the excellent intubation condition,but the clinical effective duration is more longer than that of 2×ED_(95) rocuronium.
出处
《中华麻醉学杂志》
CAS
CSCD
北大核心
1997年第11期656-659,共4页
Chinese Journal of Anesthesiology
关键词
罗库溴铵
琥珀胆碱
药理学
Rocuronium
Succinylcholine
Pharmacodynamics
Intubation
