摘要
目的：研究丝瓜叶新成分Ｌ６ａ和Ｌ１０对大鼠学习记忆及海马内生长抑素的影响．方法：ｉｃｖ大鼠分别用穿梭箱被动回避反应及免疫组化、图像分析等法进行．结果：Ｌ６ａ（２５μｇ）组记忆保持功能明显增强（Ｐ＜００５），生长抑素免疫反应物（ＳｏｍＬＩ）的面密度和数密度显著增加（Ｐ＜００５）；其余各组记忆保持功能增加不显著（Ｐ＞００５），Ｌ１０（２５μｇ）组ＳｏｍＬＩ的面密度及（５０μｇ）组ＳｏｍＬＩ的面密度和数密度值均显著增加（Ｐ＜００５）．结论：Ｌ６ａ（２５μｇ）具有增强记忆保持功能和增加ＳｏｍＬＩ的作用，Ｌ１０有增强记忆保持功能的趋势，但不显著，却显著增加海马内的ＳｏｍＬＩ．
IM: To study the effects of two constituents L 6a and L 10 from the leaves of Luffa cylinderica Roem on learning, memory, and hippocampal somatostatin in rats. METHODS: The learning and memory in rats were determined using the passive avoidance response of shuttle box, by icv. Somatostatin in hippocampus was determined with immunohistochemical and images analyses. RESULTS: L 6a 25 μg raised memory keeping activity ( P <0 05) in rats. L 6a 25 μg increased the surface density and number density of somatostatin like immureactant (Som LI) ( P <0 05). L 10 25 and 50 μg increased the surface density and number density of Som LI ( P <0.05). CONCLUSION: L 6a 25 μg enhanced memory keeping activity and increased the surface density and number density of Som LI in rats. L 10 shows a tendency to enhance memory keeping activity but no evident, but it increases the surface density and number density of Som LI.
出处
《中国药理学报》
CSCD
1997年第6期529-531,共3页
Acta Pharmacologica Sinica
关键词
学习记忆
海马
生长抑素
L-6a
L-10
丝瓜
叶
L 6a
L 10
Luffa cylinderica Roem
learning
memory
hippocampus
somatostatin
