摘要
目的:观察芒果苷(mangiferin)对异丙肾上腺素(isoproteronol,ISO)诱发的小鼠心肌缺血的影响。方法:采用腹腔注射ISO建立小鼠急性心肌缺血模型,观察芒果苷对小鼠Ⅱ导联心电图(ECG),心肌超氧化物岐化酶(SOD),丙二醛(MDA)及血清磷酸肌酸激酶(CK)和乳酸脱氢酶(LDH)的影响。结果:芒果苷对ISO诱发小鼠Ⅱ导联ECG异常有改善。芒果苷使心肌SOD活性明显升高,使心肌MDA含量、血清CK及LDH水平降低。结论:芒果苷对异丙肾上腺素诱发的小鼠心肌缺血的损伤有保护作用。
Objective： To evaluate the protective effect of mangiferin （MAN） on myocardial ischemia induced by isoproteronol （ISO） in mice. Methoths： Acute myocardial ischemic model induced by intraperitoneal administration of ISO in mice was adopted to observe the effects of MAN on the abnormality in lead Ⅱ on ECG,the myocardial contents of SOD and MDA,the serum levels of LDH and CK. Results： MAN could ameliorate the abnormal changesof ECG,could increase the myocardial activity of SOD and could decrease the myocardial contents of MDA, the serum levels of CK and LDH. Conclusion： MAN has protective effect on myocardial ischemia induced by ISO in mice.
出处
《中药药理与临床》
CAS
CSCD
北大核心
2008年第2期16-18,共3页
Pharmacology and Clinics of Chinese Materia Medica
