摘要
目的研究抑癌基因PTEN在乳腺癌中的表达及其临床意义。方法采用免疫组化技术(S-P)检测72例乳腺癌中PTEN的表达情况。结果PTEN总的表达缺失率为62.5%(45/72)。PTEN表达缺失率与乳腺癌的组织学分级,TNM临床分期,腋窝淋巴结转移和生存时间有关(P<0.05),而与肿瘤的大小和ER、PR状况无关。结论检测乳腺癌PTEN在蛋白水平的表达缺失状况可能有助于对其预后的判断。
Objective To study the expression and clinical significance of tumor suppressor gene PTEN in breast cancer. Methods Immunohistochemieal staining（S-P） was used to detect the expression of PTEN in 72 cases of breast cancer samples. Results Among these 72 samples,the rates of total expressing depletion of PTEN were 62.5% （45/72）. The rates of total expressing depletion of PTEN was significantly correlated with histological grade, TNM staging,axillary lymph nodes status and survival time （ P 〈 0.05 ）, but not with tumor size, estrogen and progesterone receptors. Conclusions The depletion of the expression of PTEN at protein level may contribute to prognostic criterion for breast cancer
出处
《实用全科医学》
2008年第6期555-556,共2页
Applied Journal Of General Practice
基金
安徽省高校省级自然科学研究项目(KJ2007B378IC)
关键词
抑癌基因PTEN
免疫组织化学
乳腺癌
Tumor suppressor gene PTEN
Immunohistochemistry
Breast cancer
