摘要
哮喘患儿气道炎症形成和发展过程中,细胞因子和炎性介质起着重要的作用,随着大多数炎性介质性质被确定,炎性介质特异性的受体拮抗剂:组胺受体阻断剂、白三烯受体拮抗剂、血栓素受体拮抗剂、血小板激活因子拮抗剂、白细胞介素(IL)受体拮抗剂、抗IgE抗体治疗、神经激肽受体拮抗剂、内皮素受体拮抗剂等也被发现。受体拮抗剂的研究和应用也成为哮喘防治的热点,但如何根据不同的患者选择不同的炎性介质拮抗剂进行有效的哮喘治疗仍需更多、更深入的研究。
Inflammatory factors and cytokines play important roles in the formation and developing of airway inflammation in asthmatic children.With the definition of most of inflammatory factors,their specific receptor antagonists also have been found,which includes histamine receptor blocking pharmacon,leukotriene receptor antagonist,thromboxane receptor antagonist,platelet activating factor antagonist,interleukin receptor antagonist,anti-immunoglobulin E therapy,neurokinin receptor antagonist and endothelin receptor antagonist.The study and application of receptor antagonist have been the hot spot in the prevention and therapy of anthma.How to select different inflammatory factors antagonist according to different patients for the effective therapy for anthma still needs further and more studying.
出处
《医学综述》
2008年第11期1713-1714,共2页
Medical Recapitulate
关键词
哮喘
炎性介质
细胞因子
拮抗剂
治疗
儿童
Asthma
Inflammatory factor
Cytokine
Antagonist
Treatment
Children
