摘要
用免疫组织化学染色方法，对30例幽门螺杆菌（HP）相关慢性胃炎和15侧HP阴性胃粘膜基本正常者胃粘膜中增殖细胞核抗原（PCNA）标记指数（LI％）和表皮生长因子受体（gnF-）的表达进行了检测。结果表明，HP阳性患者PCNALI％为13．94士1．64，HP阴性对照组为7．71士0．92，有显著差别（P＜0．001）。EGF-R表达与PCNA呈正相关（r=0.4487，P＜0．01）。PCNALI％及EGF-R表达与胃粘膜炎症程度无相关（P＞0.05）。提示，HP感染能引起胃粘膜上皮细胞过度增殖。这为阐明Hp感染在胃癌发病中作用的机理提供了线索。
Helicobacter pylori (Hp) infection is the main cause of chronic gastritis, which frequently leads to the at-rophy and intestinal metaplasia of the underlying gastric mucosa, and rarely to gastric cancer. The hyperproliferation ofcells is linked to malignant transformation. The aim of this study was to investigate the relationship between Hp infec-tion and the gastric epithelial proliferation. Thirty chronic gastritis patients with Hp infection and l5 norma1 controlsproved by endoscopy, histopathology, urease test and bacterial culture were inc1uded in this study. Proliferating cell nu-clear antigen (PCNA) labeling index (LI)% was used as marker of cell proliferation. PCNA LI and expression of epi-dermal growth factor receptor (EGF-R) were detected by immunohistochemistry. PCNA LI% in 30 chronic gastritis pa-tients with Hp infection was 13. 941 1. 64, significantly higher than 7. 71 1 0. 92 in 15 normal contrl os(P<o. OO1 ). Theexpression of EGF-R was positively correlated with PCNA LI% (P<0.00l ). PCNA LI% was not correlated with thedegree of inflammation in the gastric mucosa. Hp infection is associated with both the gastric epithelial hyperprolifer-ation and the increased expression of EGF-R, through which Hp infection may link to the development of gastric cancer.
出处
《上海医学》
CAS
CSCD
北大核心
1997年第11期624-626,共3页
Shanghai Medical Journal
