摘要
目的比较用胰岛素泵输注速效胰岛素类似物(诺和锐)和短效人胰岛素(诺和灵R)治疗老年2型糖尿病高血糖的疗效差异。方法55例住院需胰岛素治疗的老年2型糖尿病患者随机分为两组:诺和锐组和诺和灵R组,胰岛素泵治疗2周,比较两组患者治疗过程中每日3餐前后和睡前血糖、血糖达标所需天数及胰岛素量、低血糖发生率。结果3餐前和睡前血糖下降两组间差异无显著性(P>0.05)。诺和锐组血糖控制达标快于诺和灵R组(P<0.01),餐后血糖指标好于诺和灵R组(P<0.05),胰岛素用量和低血糖发生率低于诺和灵R组(P<0.05)。结论用胰岛素泵输注诺和锐及诺和灵R均能使老年2型糖尿病高血糖状态得到良好控制,但诺和锐对餐后血糖控制更理想,血糖控制达标时所需时间更短,所需胰岛素量更少,低血糖发生率更低。
[Objective] To compare the efficiency of insulin aspart and human regular insulin（NOVO R） via continuous subcutaneous insulin infusion（CSⅡ） pump on hyperglycemia in elderly patients with type 2 diabetes. [Methods] 55 hospitalized patients with type 2 diabetes who had poorly controlled blood glucose were randomly divided into 2 groups to undergo insulin pump therapy with aspart or NOVO R for two weeks, the changes of blood glucose（include before and after three meals and bedtime）, the time and the dose of insulin needed for good glycemia control were compared between two groups, the frequency of hypoglycemia was recorded. [Result] No significant differences in blood glucose between the two groups were observed in bedtime and before three meals（P 〉0.05）, the time for good glycemia control was shorter in the aspart group than in NOVO R group（P 〈0.01）,postprandial blood glucose after 3 meals and the mean dose of insulin used and the frequency of hypoglycemia in the aspart group were significantly lower in the aspart group than in the NOVO R group （P 〈0.05）. [Conclusion] Insulin aspart via CSⅡ is as efficacious as NOVO R in controlling hyperglycemia in elderly type 2 diabetes, but insulin aspart provides a more effective and faster control of postprandial hyperglycemia with less insulin used and lower frequency of hypoglycemia.
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2008年第10期1331-1334,共4页
China Journal of Modern Medicine
