摘要
为探讨藻藻酯双酯钠(PSS)和甘糖酯(PGMS)对急性心肌梗死(AMI)患者红细胞变形能力(ED)保护作用的机制,检测了52例AMI患者红细胞滤过指数(EFI)、红细胞膜Na^+,K^+ -ATP酶和谷胱甘肽过氧化物酶GSH-Px活性及红细胞膜脂质过氧化物(LPO)的变化,同时观察了PSS和PGMS在体外对ED、Na^+,K^+ -ATP酶、GSH-Px和LPO的影响。结果显示,AMI患者EFI、LPO明显增高,Na^+,K^+ -ATP酶和GSH-Px活性明显降低,与对照组比较差异有极显著性(P<0.001)。AMI患者红细胞与PSS或PGMS在体外温育24h后,EFI、LPO明显降低,Na^+,K^+ -ATP酶和GSH-Px活性明显增高。与温育前比较差异有极显著性(P<0.001),与对照组比较差异无显著性(P>0.05)。提示PSS和PGMS具有保护和提高AMI患者ED的作用,其机制与增强红细胞膜ATP酶和抗氧化酶活性有关。
To explore the mechanism of protecting erythrocyte deformability (ED) of polysaccharide sulfate(PSS)and propyllene glycolmannurate sulfate(PGMS) in patients with acute myocardial infarction (AMI). The erythrocyte filtration index(EFI),erythrocgte membrane Na+,K+-ATPase .glutathione peroxidase(GSH-Px)activity and lipid peroxide(LPO) were measured in 52 patients with AMI. Meanwhile the effects of PSS and PGMS on EFI, Na+,K+-ATPase ,GSH-Px and LPO in AMI patients were observed in vitro. The results showed that the EFI and LPO were markedly higher ,Na+ ,K+-ATP ase and GSH-Px were si-hnificantly lower in patients than those in control(P<0. 001),when AMI patients erythrocyte incubated with PSS or PGMS for 24 hours ,the EFI and LPO were markedly lower, Na+,K+-ATPase and GSH-Px were markedly higher,as compared with the group before the incubation(P<0. 001),but there was no significance compared with controls before and after incubation (P>0. 05). These results indicate that PSS and PGMS could improve the ED in patients ,and the efficacy of PSS or PGMS was related to enchancement of erythrocyte membrane ATP-ase anci GSH-Px activity.
出处
《中国海洋药物》
CAS
CSCD
1997年第4期12-15,共4页
Chinese Journal of Marine Drugs
关键词
心肌梗塞
红细胞
变形能力
藻酸双脂钠
甘糖酯
PSS
PGMS
myocardial infarction
erythrocyte deformability
adenosine triphosphatase
glutathione peroxidase
