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猪肌肉注射硫酸头孢喹肟注射液的安全性试验 被引量:6

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摘要 本试验对硫酸头孢喹肟进行了大、小鼠经口的急性毒性试验和猪肌肉注射硫酸头孢喹肟的安全性研究。选用SD大鼠和ICR小鼠各30只,其经口LD50均大于5000mg/kg。随机挑选健康猪12头,分为3组,按2mg/kg、6mg/kg和10mg/kg剂量颈部肌肉注射硫酸头孢喹肟注射液,每日1次,连续5d。对其给药前后的血常规和血液生化指标分析比较,并每天观察给药后动物临床表现。试验结果显示:硫酸头孢喹肟注射液在2~10mg/kg剂量范围对猪血液生理生化指标无显著影响(P〉0.05),所有动物给药后采食、行动、呼吸和排泄均未见异常,注射部位未见肿胀结块等现象,除10mg/kg剂量组动物出现短时疼痛反应外,未观察到任何不良反应。
出处 《畜牧与兽医》 北大核心 2008年第6期76-78,共3页 Animal Husbandry & Veterinary Medicine
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参考文献4

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