摘要
为探讨CA125在肺癌诊断、鉴别诊断、分期中的应用，采用免疫放射分析法测定50例肺癌患者血清CA125水平，结果显示：肺癌患者血清CA125水平显著增高，其增高的程度与肺癌TNM分期直接相关，依次为IV期＞III期＞II期＞I期，其中鳞癌、腺癌、小细胞未分化癌患者血清CA125水平差异无显著性，以12U／ml为临界值，与正常对照组相比，血清CA125测定诊断肺癌的敏感度为67．4％，特异度100％；准确度84．27％；与脑部良性病变组比较，上述值分别为：67．4％，82．14％和71．83％。表明血清CA125测定对于肺癌的诊断、鉴别诊断和分期具有重要的意义。
In order to elucidate the role of CA125 in the diagnosis, differential diagnosis and stage division of lung cancer,we meased the serum levels of CA125 in 50 patients with lung cancer by a two - step im-munoradiometric assay. Results: The serum CA125 level in lung cancer group was significantly higher than that in normal control group and benign pulmonary disease group.The degree of incarease was directly as-sociated with the TNM stage,with the sequence of stage IV>stage III>stage II>stage I. No significant difference was observed in squamous cell lung cancer group, adenocarcinoma group and small cell lung cancer group, Taking 12U/ml as a critical value, in contrast to the normal control group, the sensitivity of serum CA125 assay in the diagnosis of lung cancer was 67.4%, the specificity 100%, the accuracy 84.27%;In contrast to the benign pulmonary disease group, the values were 67.4%, 82.14% and 71.83%. Conclusion: The assay of serum CA125 has a certain practical value for the diagnosis, differential diagnosis and stage - division of lung cancer.
出处
《河南肿瘤学杂志》
1997年第6期432-434,共3页
Henan Journal of Oncology
