摘要
目的探讨获得性免疫缺陷综合征合并肺结核（AIDS／PTB）双重感染的类型，影像特征及临床表现为PTB菌阴及菌阳时，患者T细胞亚群计数的差异及意义。方法 回顾性分析93例AIDS／PTB双重感染患者的类型，影像特征及临床表现分别为PTB菌阴及菌阳时，检测其T细胞亚群水平并进行统计学比较。结果①CD4^＋细胞计数与结核病的发病率成反比，当CD4＋〈50×106^／L时，结核的发病率明显上升（67．74％，63／93）。②影像特征不典型的PTB病例CD4^＋T细胞计数为（47．79±32．17）×10^6，影像特征典型的PTB病例CD4^＋T细胞计数为（95．34±64．89）×10^6／L。二者之间CD4^＋T细胞计数差异有统计学意义（P〈0．01）。③不同临床表现患者CD4^＋T细胞计数差异有统计学意义，PTB菌阴组患者明显高于PTB菌阳组患者（P〈0．02），CD8^＋T细胞计数比较差异无统计学意义（P〉0．05）。结论AIDS／PTB感染患者临床特征与其T细胞亚群计数相关。
Objective To evaluate the diversity of T lymphocyte subsets counts in acquired immunodeficiency syndrome（AIDS） patients infected with Mycobacterium tuberculosis when the clinical manifestations were pulmonary tuberculosis negative or positive,and to discuss type and chest radiological characteristics. Methods T lymphocyte subsots counts from 93 AIDS patients infected with Mycobacterium tuberculosis were analyzed,including type, chest radiological characteristics when the clinical manifestations were tuberculosis negative or positive. Results ① With the decreasing CD4^＋ counts, he tuberculosis increased. When the CD4^＋ counts were 〈 50× 106/L, the tuberculosis increased remarkably （67.74%, 63/93）. ②The CD4^＋ T lymphocytes alone were （47.79±32.17） × 10^6/L and （95.34±64.89） × 10^6/L for the not typical or typical chest radiological characteristics of tuberculosis in patients with AIDS （ P 〈0.01 ）. ③The CD4^＋ T lymphocyte counts in patients which the clinical manifestation negative were tuberculosis were obviously higher than those in patients which the clinical manifestation positive were crewels （ P 〈0.02）. Conclusions The clinical manifestation of AIDS patients complicated with pulmonary tuberculosis is obviously associated with the counts of T lymphocyte subsets.
出处
《国际呼吸杂志》
2008年第11期655-658,共4页
International Journal of Respiration
关键词
获得性免疫缺陷综合征
肺结核
T细胞亚群
Acquired immunodeficiency syndrome Pulmonary tuberculosis T lymphocyte subsets
