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SLA-DQB和DRB的生物信息学分析 被引量：2

Bioinformatic analysis of SLA-DQB and DRB
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摘要 对Genbank中猪的白细胞抗原(SLA)II类抗原基因DQB及DRB序列进行了SNP及氨基酸序列多态性分析,并对SLA-DQB及DRB分子进行了蛋白质序列模式分析(Prostie motif search)。结果表明:β1功能区存在较大的变异,特别是位于抗原肽结合槽的氨基酸位点中,其变异程度更大。SLA-DQB及DRB蛋白质序列中,主要存在8种类型的蛋白质序列模式位点,其中3种类型的磷酸化位点存在蛋白模序的改变,都位于β1功能区(前94个氨基酸),且多数位点突变频率较高。 All of the SLA - DQB and DRB gene sequences in Genbank currently were analyzed by some tools of bioinformatics. More variances exist in the β1 domain than the other regions of SLA- DQB and DRB sequences, especially in the peptide- binding groove. Three of eight types of Prestie motif existing in the SLA - DQB and DRB amino acid sequences have variances, which exist in the β1 domain.
作者 周波 黄瑞华 刘红林 王林云
机构地区 南京农业大学动物科技学院
出处 《生物信息学》 2008年第2期52-54,共3页 Chinese Journal of Bioinformatics
基金 江苏省高新技术研究项目(BG2004317) 南京农业大学校青年基金(Y200613)
关键词 SLA—DQB SLA—DRB SNP BIOINFORMATICS Prostie MOTIF SLA - DQB SLA - DRB SNP Bioinformatics Prostie motif
分类号 Q811.4 [生物学—生物工程] TU723.1 [建筑科学—建筑技术科学]
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同被引文献46

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生物信息学
2008年 第2期

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